Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals.

Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals. Research Abstract Details 

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Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals. Abstract Text:

The molecular mechanism participating in the transport of newly synthesized proteins from the cytoplasm to the nucleus in mammalian cells is poorly understood. Recently, the nuclear localization signal sequences (NLS) of many nuclear proteins have been identified, and most have been found to be composed of a highly basic amino acid stretch. A genetic "subtractive" and a biochemical "additive" approach were used in our studies to identify the NLS's of the polyomavirus structural capsid proteins. An NLS was identified at the N-terminus (Ala1-Pro-Lys-Arg-Lys-Ser-Gly-Val-Ser-Lys-Cys11) of the major capsid protein VP1 and at the C-terminus (Glu307 -Glu-Asp-Gly-Pro-Glu-Lys-Lys-Lys-Arg-Arg-Leu318) of the VP2/VP3 minor capsid proteins.

Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals. Publishing Authors By Initials

For similar viruses: dna viruses: polyomaviridae: polyomavirus research abstracts see: viruses: dna viruses: polyomaviridae: polyomavirus research

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Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Transactions of the Kansas Academy of Science. Kan

VOLUME: 96

Page Numbers: 35-9

Journal Abbreviation: Trans. Kans. Acad. Sci.

ISSN: 0022-8443

DAY: 26

MONTH: Apr

YEAR: 1993

Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals. Information

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LANGUAGE: eng

NlmUniqueID: 7506117

Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals. Keywords Mesh Terms:

KEYWORDS: Polyomavirus

MESH TERMS: metabolism

Chemical & Substance for Abstract: Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals. Information

Substance Name: Nuclear Proteins

Registry Number: 0

Grant and Affiliation Information for Identification of amino acid sequences in the polyomavirus capsid proteins that serve as nuclear localization signals.

AFFILIATION: KS St U, Manhattan

Country: UNITED STATES

AGENCY: United States NCI

GRANT: CA07319

ACRONYM: CA

MEDLINETA: Trans Kans Acad Sci

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