Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy.

Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy. Research Abstract Details 

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Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy. Abstract Text:

Xin Qin,Yi Wan,Meng Li,Xiaochang Xue,Shouzhen Wu,Cun Zhang,Yanjie You,Weihua Wang,Changli Jiang,Yan Liu,Wenhua Zhu,Yonggang Ran,Zhen Zhang,Wei Han,Yingqi Zhang,Xin Qin,Yi Wan,Meng Li,Xiaochang Xue,Shouzhen Wu,Cun Zhang,Yanjie You,Weihua Wang,Changli Jiang,Yan Liu,Wenhua Zhu,Yonggang Ran,Zhen Zhang,Wei Han,Yingqi Zhang,

Human vascular endothelia growth factor receptor 3 (VEGFR-3) is up-regulated in a variety of human cancers. It is a potentially rational target for drug delivery. To identify novel ligands with specific binding capabilities to VEGFR-3, we screened a phage display peptide library and found a consensus motif of the peptides which is displayed by the positive phages CSDxxHxWC (x is any amino acid). The phage displaying peptide CSDSWHYWC (designated as P1) exhibited the highest affinity to VEGFR-3 in phage ELISA and the chemically synthesized P1 could bind to VEGFR-3 specifically in a dose-dependent manner. In addition, the flow cytometry assay and immunofluorescence showed that the FITC labelled P1 could bind to VEGFR-3 positive carcinoma cells with specificity. Our study suggests that P1 may be a homing peptide for treatment of tumours.

Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy. Publishing Authors By Initials

X Qin,Y Wan,M Li,X Xue,S Wu,C Zhang,Y You,W Wang,C Jiang,Y Liu,W Zhu,Y Ran,Z Zhang,W Han,Y Zhang,X Qin,Y Wan,M Li,X Xue,S Wu,C Zhang,Y You,W Wang,C Jiang,Y Liu,W Zhu,Y Ran,Z Zhang,W Han,Y Zhang,

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Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 142

Page Numbers: 79-85

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 21

MONTH: 05

YEAR: 2007

Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor Recep

MESH TERMS: metabolism

Chemical & Substance for Abstract: Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy. Information

Substance Name: Vascular Endothelial Growth Factor Recep

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy.

AFFILIATION: Biotechnology Center of The Fourth Military Medical University, and State Key Laboratory of Cancer Biology, 17 Chang'le West Road, 710032 Xi'an, People's Republic of China.

Country: Japan

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MEDLINETA: J Biochem (Tokyo)

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