Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G.

Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G. Research Abstract Details 

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Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G. Abstract Text:

Rebecca L R Powell,Jiangqin Zhao,Frank A J Konings,Shixing Tang,Aubin Nanfack,Sherri Burda,Mateusz M Urbanski,D R Saa,Indira Hewlett,Phillipe N Nyambi,Rebecca L R Powell,Jiangqin Zhao,Frank A J Konings,Shixing Tang,Aubin Nanfack,Sherri Burda,Mateusz M Urbanski,D R Saa,Indira Hewlett,Phillipe N Nyambi,

An array of CRFs have been identified in Cameroon, the most notable being CRF02_AG. HIV-1 in the East Province of Cameroon is particularly diverse: in a recent study, we found a high proportion of unique recombinant forms (URFs). Herein we describe the analysis of the full-length sequences of two of these URFs, which, after preliminary analysis of gag, pol, and env fragments, appeared to be a novel CRF. This novel strain, CRF36_cpx, contains fragments that can be assigned to the CRF01_AE, CRF02_AG, and subtype A and G radiations. Forty percent of the genome can be classified as CRF02_AG, including regions in gag, pol, env, and the accessory genes. Twenty-seven percent is CRF01_AE, comprising the majority of gag, the beginning of env, and the end of env into the 3' LTR. Twenty percent of the genome can be assigned to subtype A, with segments in pol and env. The remaining 13% of the sequence is classifiable as subtype G, in pol and vpu. The subtype A and G lineages formed by the CRF36_cpx sequences are unique and appear ancestral in nature. CRF36_cpx is both the first to combine more than one CRF and the first to include fragments of CRF02_AG. The ancestral sequences present in CRF36_cpx represent a link to extinct strains, and, potentially, insight into the evolution of HIV-1.

Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G. Publishing Authors By Initials

RL Powell,J Zhao,FA Konings,S Tang,A Nanfack,S Burda,MM Urbanski,DR Saa,I Hewlett,PN Nyambi,RL Powell,J Zhao,FA Konings,S Tang,A Nanfack,S Burda,MM Urbanski,DR Saa,I Hewlett,PN Nyambi,

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Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AIDS research and human retroviruses

VOLUME: 23

Page Numbers: 1008-19

Journal Abbreviation: AIDS Res. Hum. Retroviruses

ISSN: 0889-2229

DAY: 29

MONTH: Aug

YEAR: 2007

Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G. Information

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LANGUAGE: eng

NlmUniqueID: 8709376

Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G. Keywords Mesh Terms:

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Grant and Affiliation Information for Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and G.

AFFILIATION: Department of Microbiology, New York University School of Medicine, New York, New York 10010, USA.

Country: United States

AGENCY: United States FIC

GRANT: TW01409

ACRONYM: TW

MEDLINETA: AIDS Res Hum Retroviruses

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ACCESSION NUMBER: EF087995

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Identification of a novel circulating recombinant form CRF 36_cpx in Cameroon that combines two CRFs 01_AE and 02_AG with ancestral lineages of subtypes A and G Related Publications

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