Identification of a forskolin-like molecule in human renal cysts.

Identification of a forskolin-like molecule in human renal cysts. Research Abstract Details 

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Identification of a forskolin-like molecule in human renal cysts. Abstract Text:

William C Putnam,Sarah M Swenson,Gail A Reif,Darren P Wallace,George M Helmkamp,Jared J Grantham,

Renal cyst enlargement is increased by adenosine cAMP, which is produced within mural epithelial cells. In a search for modulators of cAMP synthesis cyst fluids from 18 patients with autosomal dominant or recessive polycystic kidney disease (PKD) were analyzed, and in 15 of them, a stable lipophilic molecule that increased cAMP levels, stimulated transepithelial chloride and fluid secretion, and promoted the proliferation of human cyst epithelial cells was characterized. With the use of HPLC-mass spectrometry, a bioactive lipid with the same mass spectral fingerprint, the same chromatographic retention time, and the same biologic properties as forskolin, a widely known, potent adenylyl cyclase agonist, has been isolated and identified within the cyst fluid. Forskolin is synthesized by the plant Coleus forskohlii, but its appearance or compounds like it have not been reported in animals. The origin of forskolin in patients with PKD was not revealed by this study. Synthesis by mural cyst epithelial cells or an exogenous source are the most likely possibilities. Forskolin is sold for weight management and as a cardiovascular tonic in health stores and through the Worldwide Web. It is concluded that forskolin may have a role in promoting the enlargement of cysts in autosomal dominant PKD and recommended that patients avoid oral and parenteral preparations that contain this compound.

Identification of a forskolin-like molecule in human renal cysts. Publishing Authors By Initials

WC Putnam,SM Swenson,GA Reif,DP Wallace,GM Helmkamp,JJ Grantham,

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Identification of a forskolin-like molecule in human renal cysts. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Society of Nephrology : JA

VOLUME: 18

Page Numbers: 934-43

Journal Abbreviation: J. Am. Soc. Nephrol.

ISSN: 1046-6673

DAY: 24

MONTH: 01

YEAR: 2007

Identification of a forskolin-like molecule in human renal cysts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9013836

Identification of a forskolin-like molecule in human renal cysts. Keywords Mesh Terms:

KEYWORDS: Polycystic Kidney Diseases

MESH TERMS: pathology

Chemical & Substance for Abstract: Identification of a forskolin-like molecule in human renal cysts. Information

Substance Name: Forskolin

Registry Number: 66428-89-5

Grant and Affiliation Information for Identification of a forskolin-like molecule in human renal cysts.

AFFILIATION: Midwest Research Institute, Kansas City, Missouri, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: P50 DK 57301

ACRONYM: DK

MEDLINETA: J Am Soc Nephrol

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