Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila.

Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila. Research Abstract Details 

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Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila. Abstract Text:

Kathleen M Gajewski,Richard P Sorrentino,Joong H Lee,Qian Zhang,Mark Russell,Robert A Schulz,

In Drosophila, Black cells (Bc) encodes a Prophenoloxidase and is expressed late in the maturation of crystal cells, which are blood cells involved in wound healing and immune encapsulation. Enhancer analysis of Bc revealed a 1,025-bp upstream sequence that regulates gene expression in a crystal cell exclusive pattern. Expression of this fragment is altered by mutations in the GATA family serpent (srp) and RUNX family lozenge (lz) genes; Srp and Lz are required for crystal cell specification. Deletional analysis uncovered a 330-bp crystal cell-specific sequence, which contains two GATA and three Lz binding sites. Mutational analysis revealed that both GATA sites are necessary, but not sufficient for crystal cell expression. However, one of the Lz sites is essential for crystal cell expression. Thus, Srp and Lz do not just specify the crystal cell lineage, but also regulate the later differentiation of these cells. Additionally, we now have a sensitive tool for marking crystal cells in live animals.

Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila. Publishing Authors By Initials

KM Gajewski,RP Sorrentino,JH Lee,Q Zhang,M Russell,RA Schulz,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genesis (New York, N.Y. : 2000)

VOLUME: 45

Page Numbers: 200-7

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ISSN: 1526-954X

DAY: 3

MONTH: Apr

YEAR: 2007

Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila. Information

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LANGUAGE: eng

NlmUniqueID: 100931242

Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila. Information

Substance Name: Catechol Oxidase

Registry Number: EC 1.10.3.1

Grant and Affiliation Information for Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila.

AFFILIATION: Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

Country: United States

AGENCY: United States NICHD

GRANT: T32HD007325

ACRONYM: HD

MEDLINETA: Genesis

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