Identification of a biomarker for sleep drive in flies and humans.

Identification of a biomarker for sleep drive in flies and humans. Research Abstract Details 

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Identification of a biomarker for sleep drive in flies and humans. Abstract Text:

Laurent Seugnet,Jaime Boero,Laura Gottschalk,Stephen P Duntley,Paul J Shaw,

It is a common experience to sacrifice sleep to meet the demands of our 24-h society. Current estimates reveal that as a society, we sleep on average 2 h less than we did 40 years ago. This level of sleep restriction results in negative health outcomes and is sufficient to produce cognitive deficits and reduced attention and is associated with increased risk for traffic and occupational accidents. Unfortunately, there is no simple quantifiable marker that can detect an individual who is excessively sleepy before adverse outcomes become evident. To address this issue, we have developed a simple and effective strategy for identifying biomarkers of sleepiness by using genetic and pharmacological tools that dissociate sleep drive from wake time in the model organism Drosophila melanogaster. These studies have identified a biomarker, Amylase, that is highly correlated with sleep drive. More importantly, both salivary Amylase activity and mRNA levels are also responsive to extended waking in humans. These data indicate that the fly is relevant for human sleep research and represents a first step in developing an effective method for detecting sleepiness in vulnerable populations.

Identification of a biomarker for sleep drive in flies and humans. Publishing Authors By Initials

L Seugnet,J Boero,L Gottschalk,SP Duntley,PJ Shaw,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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MEDLINE DATE:

Identification of a biomarker for sleep drive in flies and humans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 19913-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 13

MONTH: 12

YEAR: 2006

Identification of a biomarker for sleep drive in flies and humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Identification of a biomarker for sleep drive in flies and humans. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: genetics

Chemical & Substance for Abstract: Identification of a biomarker for sleep drive in flies and humans. Information

Substance Name: Amylases

Registry Number: EC 3.2.1.-

Grant and Affiliation Information for Identification of a biomarker for sleep drive in flies and humans.

AFFILIATION: Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01-NS051305-01A1

ACRONYM: NS

MEDLINETA: Proc Natl Acad Sci U S A

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