Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula.

Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. Research Abstract Details 

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Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. Abstract Text:

Prakash Bhosale,Da You Zhao,Bogdan Serban,Paul S Bernstein,

PURPOSE: The xanthophyll carotenoids lutein and zeaxanthin, along with their major metabolites, meso-zeaxanthin, and 3'-oxolutein, are highly concentrated in the human macula. In addition to these two metabolites, there are still others that have not yet been identified. A highly sensitive HPLC-mass spectral method was used to identify and quantify a new xanthophyll metabolite that increases with age. METHODS: Maculae (4-mm diameter) from donor eyes free of ocular disease were procured from the local eye bank. The carotenoid extracts from each tissue sample were analyzed by HPLC coupled with an in-line single quadrupole mass spectrometer in a positive ion atmospheric pressure chemical ionization mode. The elution profile, visible absorption spectra and mass spectra were compared to synthetic standards to identify the ocular carotenoids and their metabolites. RESULTS: Along with 3'-oxolutein and meso-zeaxanthin, a relatively nonpolar zeaxanthin derivative was identified, with m/z 582.5 and spectral properties similar to those of dietary zeaxanthin. This compound was identified as 3-methoxyzeaxanthin (3-MZ) based on elution profile, absorption spectra, and mass spectra in comparison to a synthetic standard. 3-MZ increased with age (P < 0.001) and was not detectable in peripheral retina or in nonretinal tissues. CONCLUSIONS: Identification of 3-MZ in the macula of aged donors indicates that O-methylation of carotenoids is a potential biomarker for aging and age-related ocular disorders.

Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. Publishing Authors By Initials

P Bhosale,da Y Zhao,B Serban,PS Bernstein,

For similar organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: xanthophylls research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: xanthophylls research

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Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Investigative ophthalmology & visual science

VOLUME: 48

Page Numbers: 1435-40

Journal Abbreviation: Invest. Ophthalmol. Vis. Sci.

ISSN: 0146-0404

DAY: 3

MONTH: Apr

YEAR: 2007

Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7703701

Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. Keywords Mesh Terms:

KEYWORDS: Xanthophylls

MESH TERMS: chemistry

Chemical & Substance for Abstract: Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. Information

Substance Name: zeaxanthin

Registry Number: 144-68-3

Grant and Affiliation Information for Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula.

AFFILIATION: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY 11600

ACRONYM: EY

MEDLINETA: Invest Ophthalmol Vis Sci

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