Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase.

Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Research Abstract Details 

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Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Abstract Text:

Jun-Ya Kinoshita,Katsuyoshi Mihara,Toshihiko Oka,Jun-Ya Kinoshita,Katsuyoshi Mihara,Toshihiko Oka,

Newly synthesized precursors are transported into mitochondria through an outer membrane translocase, TOM. Tom40, a central pore-forming component, interacts directly with precursors to help them translocate across the outer membrane. We identified a new isoform of rat Tom40, Tom40B, which is conserved among mammals and exhibits significant similarities to Tom40 in other eukaryotes. Tom40B is an integral protein localized on the mitochondrial outer membrane, and expressed widely in all tissues examined except testis. Deletion mutant analysis revealed that the 28 amino acid residues at the carboxyl terminus were crucial for the mitochondrial targeting of Tom40B. Tom40B co-precipitated with other Tom components and formed a large protein complex. Furthermore, Tom40B directly bound to precursors of the matrix-targeted proteins with high affinities, comparable to those of Tom40A, a previously identified isoform. These findings indicate that Tom40B is a functional component of mitochondrial outer membrane translocase.

Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Publishing Authors By Initials

JY Kinoshita,K Mihara,T Oka,JY Kinoshita,K Mihara,T Oka,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 141

Page Numbers: 897-906

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 16

MONTH: 04

YEAR: 2007

Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: metabolism

Chemical & Substance for Abstract: Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase. Information

Substance Name: TOM40 protein, rat

Registry Number: 0

Grant and Affiliation Information for Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase.

AFFILIATION: Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.

Country: Japan

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MEDLINETA: J Biochem (Tokyo)

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