I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius.

I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Research Abstract Details 

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I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Abstract Text:

Manuel B Aguilar,Estuardo ,Edgar P Heimer de la Cotera, ,Baldomero M Olivera, Maillo,

Peptide sr11a was purified from the venom of Conus spurius, a vermivorous cone snail collected in the Yucatan Channel, in the Western Atlantic. Its primary structure was determined by automatic Edman degradation after reduction and alkylation. Its molecular mass, as determined by MALDI-TOF mass spectrometry (average mass 3650.77 Da), confirmed the chemical data (calculated average mass, 3651.13 Da). The sequence of peptide sr11a (CRTEGMSCgamma gamma NQQCCWRSCCRGECEAPCRFGP&; gamma, gamma-carboxy-Glu; &, amidated C-terminus) shows eight Cys residues arranged in the pattern that defines the I-superfamily of conotoxins. Peptide sr11a contains two gamma-carboxy-Glu residues, a post-translational modification that has been found in other I-conotoxins from species that live in the West Pacific: r11e from the piscivorous Conus radiatus, and kappa-BtX from the vermivorous Conus betulinus. Peptide sr11a is the eighth I-conotoxin isolated from a Conus venom and the first I-conotoxin from a species from the Western Atlantic. Peptide sr11a produced stiffening of body, limbs and tail when injected intracranially into mice.

I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Publishing Authors By Initials

MB Aguilar,E ,EP Heimer de la Cotera,A ,BM Olivera,M Maillo,

For similar animal structures: tail research abstracts see: animal structures: tail research

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I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Peptides

VOLUME: 28

Page Numbers: 18-23

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 12

MONTH: 12

YEAR: 2006

I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Information

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LANGUAGE: eng

NlmUniqueID: 8008690

I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Keywords Mesh Terms:

KEYWORDS: Tail

MESH TERMS: pathology

Chemical & Substance for Abstract: I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Information

Substance Name: Mollusk Venoms

Registry Number: 0

Grant and Affiliation Information for I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius.

AFFILIATION: Laboratorio de Neurofarmacología Marina, Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro 76230, México. maguiler@servidor.unam.mx

Country: United States

AGENCY: United States NIGMS

GRANT: GM 78677

ACRONYM: GM

MEDLINETA: Peptides

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