Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation.

Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation. Research Abstract Details 

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Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation. Abstract Text:

Wei Wei,Xiao Dan Yu,Wei Wei,Xiao Dan Yu,Wei Wei,Xiao Dan Yu,

As a transcription factor family dependent of oxygen, hypoxia-inducible factors (HIFs) play important roles in organic and cellular homeostasis, which are master regulators of tumorigenesis, angiogenesis and embryogenesis. Up to date, some known posttranslational modifications, such as hydroxylation, acetylation, phosphorylation and S-nitrosylation, have been proved to influence protein stability and transcriptional activity of HIFs. On the other hand, HIFs can be physiologically degraded through ubiquitin-dependent or -independent proteasome pathway. Two biochemical processes involve in many modulators, which are correlated and compose an intricate mechanism to control the biological function of HIFs systemically. Herein, we review and discuss the diverse roles of involved modulators in both HIFs stability and degradation, describe the potential link between the two molecular scenarios.

Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation. Publishing Authors By Initials

W Wei,XD Yu,W Wei,XD Yu,W Wei,XD Yu,

For similar genetic processes: gene expression regulation: protein modification, translational research abstracts see: genetic processes: gene expression regulation: protein modification, translational research

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Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation. Journal Published:

PUBLICATION TYPE: Review

Journal: Cancer letters

VOLUME: 257

Page Numbers: 145-56

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 18

MONTH: Nov

YEAR: 2007

Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation. Information

Number of References: 99

LANGUAGE: eng

NlmUniqueID: 7600053

Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation. Keywords Mesh Terms:

KEYWORDS: Protein Modification, Translational

MESH TERMS: metabolism

Chemical & Substance for Abstract: Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Hypoxia-inducible factors: crosstalk between their protein stability and protein degradation.

AFFILIATION: Department of Pathobiology, Institute of Basic Medical Sciences, Beijing 100850, China.

Country: Ireland

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MEDLINETA: Cancer Lett

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