Hypoxia increases BK channel activity in the inner mitochondrial membrane.

Hypoxia increases BK channel activity in the inner mitochondrial membrane. Research Abstract Details 

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Hypoxia increases BK channel activity in the inner mitochondrial membrane. Abstract Text:

Xiang Q Gu,Detlef Siemen,Suhel Parvez,Yu Cheng,Jin Xue,Dan Zhou,Xiaolu Sun,Elizabeth A Jonas,Gabriel G Haddad,

To explore the potential function of the BK channel in the inner mitochondrial membrane under physiological and hypoxic conditions, we used on-mitoplast and whole-mitoplast patches. Single BK channels had a conductance of 276+/-9 pS under symmetrical K(+) solutions, were Ca(2+)- and voltage-dependent and were inhibited by 0.1 microM charybdotoxin. In response to hypoxia, BK increased open probability, shifted its reversal potential (9.3+/-2.4 mV) in the positive direction and did not change its conductance. We conclude that (1) the properties at rest of this mitoplast K(+) channel are similar to those of BK channels in the plasma membrane; (2) hypoxia induces an increase, rather than a decrease (as in the plasmalemma), in the open probability of this K(+) channel, leading to K(+) efflux from the mitochondrial matrix to the outside. We speculate that this increase in K(+) efflux from mitochondria into the cytosol is important during hypoxia in maintaining cytosolic K(+).

Hypoxia increases BK channel activity in the inner mitochondrial membrane. Publishing Authors By Initials

XQ Gu,D Siemen,S Parvez,Y Cheng,J Xue,D Zhou,X Sun,EA Jonas,GG Haddad,

For similar inorganic chemicals: elements: metals, alkali: potassium research abstracts see: inorganic chemicals: elements: metals, alkali: potassium research

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Hypoxia increases BK channel activity in the inner mitochondrial membrane. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 358

Page Numbers: 311-6

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 25

MONTH: 04

YEAR: 2007

Hypoxia increases BK channel activity in the inner mitochondrial membrane. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Hypoxia increases BK channel activity in the inner mitochondrial membrane. Keywords Mesh Terms:

KEYWORDS: Potassium

MESH TERMS: metabolism

Chemical & Substance for Abstract: Hypoxia increases BK channel activity in the inner mitochondrial membrane. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Hypoxia increases BK channel activity in the inner mitochondrial membrane.

AFFILIATION: Department of Pediatrics (Section of Respiratory Medicine), University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0735, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS-35918

ACRONYM: NS

MEDLINETA: Biochem Biophys Res Commun

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