Hypoxia and cold stress on pulmonary venous obstruction.

Hypoxia and cold stress on pulmonary venous obstruction. Research Abstract Details 

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Hypoxia and cold stress on pulmonary venous obstruction. Abstract Text:

M Endo,M Hata,Y Saiki,S Yamaki,K Tabayashi,

Hemodynamic changes induced by hypoxia and cold stress were examined on the model of pulmonary venous obstruction (PVO) to investigate the mechanism of pulmonary hypertensive crisis. Bilateral pulmonary venous stenosis was surgically created in 7 newborn piglets of the PVO group. Sham operations were performed on 6 piglets of the control group. Following the baseline hemodynamic measurement (FiO2 = 0.3) at 8 weeks after the operation, the piglets were exposed to hypoxia (FiO2 = 0.14) for 10 minutes, and were also exposed to cold stress for 20 minutes. Hypoxia significantly increased mean pulmonary arterial pressure in the PVO group. Hypoxia increased not only pulmonary arterial resistance, but also pulmonary venous resistance in the PVO group. Cold stress did not change pulmonary arterial resistance or pulmonary venous resistance in each group. In the lungs of the PVO group, the medial muscular layer of the pulmonary arteries and pulmonary veins were thickened. This probably accelerates hypoxia-induced vasoconstriction, which in turn increases pulmonary arterial and venous resistances.

Hypoxia and cold stress on pulmonary venous obstruction. Publishing Authors By Initials

M Endo,M Hata,Y Saiki,S Yamaki,K Tabayashi,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research

PUBMED ID PMID:

MEDLINE DATE: 2001 Jul-Aug

Hypoxia and cold stress on pulmonary venous obstruction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric cardiology

VOLUME: 22

Page Numbers: 292-6

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: 02

YEAR: 2008

Hypoxia and cold stress on pulmonary venous obstruction. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Hypoxia and cold stress on pulmonary venous obstruction. Keywords Mesh Terms:

KEYWORDS: Vascular Resistance

MESH TERMS: physiology

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Grant and Affiliation Information for Hypoxia and cold stress on pulmonary venous obstruction.

AFFILIATION: Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan.

Country: United States

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MEDLINETA: Pediatr Cardiol

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