Hypothalamic-pituitary-end organ function in women with bipolar depression.

Hypothalamic-pituitary-end organ function in women with bipolar depression. Research Abstract Details 

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Hypothalamic-pituitary-end organ function in women with bipolar depression. Abstract Text:

Natalie L Rasgon,Heather A Kenna,Ma-Li Wong,Peter C Whybrow,Michael Bauer,

Disturbance of each of the three hypothalamic-pituitary-end organ systems [hypothalamic-pituitary-thyroid (HPT), -adrenal (HPA), and -gonadal (HPG)] has been reported in depressive disorders. Little is known about potential reciprocal interaction among the three HP-end organ systems in patients with depressive disorders. The present pilot study examined selective HPA and HPG hormones in a detailed time series in women with bipolar disorder (depressed type) before and after treatment with levothyroxine (L-T4), and in matched control subjects. Six medically stable, euthyroid, premenopausal women with bipolar depression, and 5 age-matched controls underwent overnight blood sampling from 2100 to 0900 h for measurement of adrenocorticotropic hormone (ACTH), cortisol, luteinizing hormone (LH), and estradiol every 15 min. Bipolar patients underwent a second overnight blood sampling procedure following 7-weeks of open-label add-on treatment with L-T4. Results revealed lower baseline cortisol parameters in bipolar patients in comparison to control subjects, while ACTH, LH, and estradiol parameters were similar. Thyroid hormones (TSH, free and total T4) were not correlated with any of the HPA or HPG hormones. ACTH and cortisol levels were correlated in control subjects, but not in bipolar patients. After L-T4 treatment, thyroid hormones increased significantly and depression scores significantly declined. No significant changes in HPA or HPG hormones parameters were observed, although the small sample size may have limited results. Upon visual inspection, ACTH and cortisol appeared to decrease after L-T4 treatment, while estradiol appeared to increase. These pilot data suggest lower levels of cortisol in women with bipolar depression, unlike previously published studies that reported higher cortisol in patients with depression. The data also suggest reciprocal changes in the HPA and HPG axes upon pharmacological modulation of the HPT system, although whether this change was due to the L-T4 treatment or the improvement of depression is unknown. The results are preliminary, and require replication in larger samples.

Hypothalamic-pituitary-end organ function in women with bipolar depression. Publishing Authors By Initials

NL Rasgon,HA Kenna,ML Wong,PC Whybrow,M Bauer,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research

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Hypothalamic-pituitary-end organ function in women with bipolar depression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychoneuroendocrinology

VOLUME: 32

Page Numbers: 279-86

Journal Abbreviation: Psychoneuroendocrinology

ISSN: 0306-4530

DAY: 20

MONTH: 02

YEAR: 2007

Hypothalamic-pituitary-end organ function in women with bipolar depression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7612148

Hypothalamic-pituitary-end organ function in women with bipolar depression. Keywords Mesh Terms:

KEYWORDS: Thyroxine

MESH TERMS: blood

Chemical & Substance for Abstract: Hypothalamic-pituitary-end organ function in women with bipolar depression. Information

Substance Name: Luteinizing Hormone

Registry Number: 9002-67-9

Grant and Affiliation Information for Hypothalamic-pituitary-end organ function in women with bipolar depression.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5723, USA. nrasgon@stanford.edu <nrasgon@stanford.edu>

Country: England

AGENCY: United States NCRR

GRANT: M01-RR00865

ACRONYM: RR

MEDLINETA: Psychoneuroendocrinology

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