Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes.

Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes. Research Abstract Details 

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Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes. Abstract Text:

Hannah Bruehl,Melanie Rueger,Isabel Dziobek,Victoria Sweat,Aziz Tirsi,Elizabeth Javier,Alyssa Arentoft,Oliver T Wolf,Antonio Convit,

CONTEXT: There is evidence of both hypothalamic-pituitary-adrenocortical (HPA) axis and cognitive dysfunction in type 2 diabetes mellitus (T2DM). However, the exact nature and the associations between these abnormalities remain unclear. OBJECTIVES: The aim of the study was to characterize the nature of the HPA dysregulation in T2DM and ascertain whether impaired cognition in T2DM could be attributed to these abnormalities. DESIGN: A cross-sectional study was performed, contrasting matched groups on HPA axis function and cognition by using the combined dexamethasone (DEX)/CRH test and a neuropsychological battery assessing declarative and working memory, attention, and executive function. SETTING: The study was conducted in a research clinic in an academic medical center. PARTICIPANTS: Participants were volunteers functioning in the cognitively normal range. We studied 30 middle-aged individuals with T2DM, on average 7.5 yr since diabetes diagnosis, and 30 age-, gender-, and education-matched controls. MAIN OUTCOME MEASURES: Basal cortisol levels, cortisol levels during the DEX/CRH test, and performance on neuropsychological tests were measured. RESULTS: Individuals with T2DM had elevated basal plasma cortisol levels, higher levels after DEX suppression, and a larger response to CRH (all P

Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes. Publishing Authors By Initials

H Bruehl,M Rueger,I Dziobek,V Sweat,A Tirsi,E Javier,A Arentoft,OT Wolf,A Convit,

For similar endocrine system: endocrine glands: pituitary-adrenal system research abstracts see: endocrine system: endocrine glands: pituitary-adrenal system research

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Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 2439-45

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 10

MONTH: 04

YEAR: 2007

Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes. Keywords Mesh Terms:

KEYWORDS: Pituitary-Adrenal System

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes. Information

Substance Name: Hydrocortisone

Registry Number: 50-23-7

Grant and Affiliation Information for Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes.

AFFILIATION: Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.

Country: United States

AGENCY: United States NIA

GRANT: P30-AG-08051

ACRONYM: AG

MEDLINETA: J Clin Endocrinol Metab

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