Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys.

Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Research Abstract Details 

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Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Abstract Text:

Patrizia Porcu,Kathleen A Grant,Heather L Green,Laura S M Rogers,A Leslie Morrow,

RATIONALE: The metabolites of deoxycorticosterone (DOC) and progesterone, allotetrahydrodeoxycorticosterone and allopregnanolone, are potent endogenous neuroactive steroids that are increased in rodent brain and plasma after hypothalamic-pituitary-adrenal (HPA) axis activation by acute stress or ethanol administration. However, little data are available for male nonhuman primates. OBJECTIVE: To determine DOC concentrations in plasma samples from 11 monkeys following challenge of the HPA axis with naloxone, corticotropin-releasing factor (CRF), dexamethasone, adrenocorticotropic hormone (ACTH) following dexamethasone pretreatment and ethanol. METHODS: DOC levels were measured in monkey plasma by radioimmunoassay. RESULTS: DOC levels were increased after naloxone (125 microg/kg and 375 microg/kg, respectively) and CRF administration (1 microg/kg), and decreased following dexamethasone (130 microg/kg) administration. ACTH (10 ng/kg) challenge, 4-6 h after 0.5 mg/kg dexamethasone, and administration of ethanol (1.0 g/kg and 1.5 g/kg) had no effect on DOC concentrations. DOC levels were positively correlated with cortisol and ACTH levels after the naloxone (375 microg/kg), CRF, and ACTH challenges. Finally, the suppression of DOC levels measured after dexamethasone was negatively correlated with subsequent alcohol self-administration. CONCLUSIONS: These results suggest that DOC levels in monkeys are regulated by the HPA axis and may contribute to physiological responses following activation.

Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Publishing Authors By Initials

P Porcu,KA Grant,HL Green,LS Rogers,AL Morrow,

For similar endocrine system: endocrine glands: pituitary-adrenal system research abstracts see: endocrine system: endocrine glands: pituitary-adrenal system research

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Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychopharmacology

VOLUME: 186

Page Numbers: 293-301

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 13

MONTH: 08

YEAR: 2005

Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Keywords Mesh Terms:

KEYWORDS: Pituitary-Adrenal System

MESH TERMS: metabolism

Chemical & Substance for Abstract: Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Information

Substance Name: Corticotropin-Releasing Hormone

Registry Number: 9015-71-8

Grant and Affiliation Information for Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys.

AFFILIATION: Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599-7178, USA.

Country: Germany

AGENCY: United States NIAAA

GRANT: U01 AA13515

ACRONYM: AA

MEDLINETA: Psychopharmacology (Berl)

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