Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice.

Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Abstract Text:

Kazunari Tanaka,Shoko Nishizono,Nozomi Makino,Shizuka Tamaru,Osamu Terai,Ikuo Ikeda,

The hypoglycemic effects of Eriobotrya japonica seeds were investigated in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats and KK-A(y) mice. The rats and mice were fed on a diet containing 10% powdered Eriobotrya japonica seeds with the coat intact for 4 months. Although the blood glucose concentration in the OLETF rats fed on the control diet without Eriobotrya japonica seeds was increased with time, the concentration in the OLETF rats fed on the diet with Eriobotrya japonica seeds was consistently low throughout the experimental period and was comparable to the level in Long-Evans Tokushima Otsuka (LETO) rats which are normal non-diabetic rats. Serum insulin was significantly lower in the OLETF rats fed on the Eriobotrya japonica seed diet than in those fed on the control diet at the termination of the experimental period. Eriobotrya japonica seeds suppressed the increment of blood glucose for 4 months and also effectively improved the glucose tolerance in the KK-A(y) mice, these actions being mainly exerted by the ethanol extract of the seeds. These results suggest that Eriobotrya japonica seeds had a hypoglycemic property and the effect is attributable to the components extracted by ethanol.

Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Publishing Authors By Initials

K Tanaka,S Nishizono,N Makino,S Tamaru,O Terai,I Ikeda,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioscience, biotechnology, and biochemistry

VOLUME: 72

Page Numbers: 686-93

Journal Abbreviation: Biosci. Biotechnol. Biochem.

ISSN: 1347-6947

DAY: 7

MONTH: 03

YEAR: 2008

Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9205717

Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice.

AFFILIATION: Graduate School of Human Health Science, Siebold University of Nagasaki, 1-1-1 Manabino, Nishisonogi-gun, Nagasaki 851-2195, Japan. katanaka@sun.ac.jp

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biosci Biotechnol Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice Related Publications

• A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis.
• Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats.
• Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.
• Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3.
• Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum.
• Compact superconducting ring at ritsumeikan university.
• Comparative evaluation of biomarkers of occupational exposure to toluene.
• Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats.
• Different effects of vitamin E on the growth and morphological differentiation of 4 murine neuroblastoma cell lines in vitro.
• Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis.
• Dyke-Davidoff-Masson syndrome manifested by seizure in late childhood: a case report.
• Early gene expression analyzed by cDNA microarray and RT-PCR in osteoblasts cultured with water-soluble and low molecular chitooligosaccharide.
• Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice.
• En bloc resection of the temporal bone by the lateral approach in carcinoma of the middle ear associated with skull base infiltration with reference to the resection of the petrous apex.
• Erythropoietin attenuates the development of experimental autoimmune myocarditis.
• Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice.
• Inhomogeneity of local temperature in small clusters in microcanonical equilibrium.
• Interactivating feedback loops within the mammalian clock: BMAL1 is negatively autoregulated and upregulated by CRY1, CRY2, and PER2.
• Lineage-specific expression of granulocyte colony-stimulating factor and thrombopoietin receptors in terminally differentiated hematopoietic cells.
• Mainstream breast cancer radiology perspective.
• Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier.
• Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test.
• Possible involvement of bone morphogenetic protein 2 in heterotopic ossification in metastatic lesion from urothelial carcinoma of bladder.
• Promising techniques for breast cancer detection, diagnosis, and staging using non-ionizing radiation imaging techniques.
• Reduced synaptic vesicle density and aberrant synaptic localization caused by a splice site mutation in the Rs1h gene.
• Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population.
• Slow absorption of conjugated linoleic acid in rat intestines, and similar absorption rates of 9c,11t-conjugated linoleic acid and 10t,12c-conjugated linoleic acid.
• Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
• Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis.
• mPer2 antisense oligonucleotides inhibit mPER2 expression but not circadian rhythms of physiological activity in cultured suprachiasmatic nucleus neurons.