Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue.

Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Abstract Text:

Masato Yoneda,Tomoyuki Iwasaki,Koji Fujita,Hiroyuki Kirikoshi,Masahiko Inamori,Yuichi Nozaki,Shiro Maeyama,Koichiro Wada,Satoru Saito,Yasuo Terauchi,Atsushi Nakajima,Masato Yoneda,Tomoyuki Iwasaki,Koji Fujita,Hiroyuki Kirikoshi,Masahiko Inamori,Yuichi Nozaki,Shiro Maeyama,Koichiro Wada,Satoru Saito,Yasuo Terauchi,Atsushi Nakajima,

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury. The spectrum of NAFLD is broad, extending from simple steatosis through nonalcoholic steatohepatitis (NASH). Insulin resistance has been found to increase the risk of NASH, and obesity, and decreased levels of adiponectin are important factors in determining the severity of insulin resistance. Recent evidence has indicated that hypoadiponectinemia is involved in hepatic steatosis and NASH. Methods: To investigate whether hypoadiponectinemia causes hepatic steatosis in type 2 diabetes mellitus (DM) patients independently of visceral adipose tissue, we measured the plasma adiponectin concentration, hepatic fat content based on the liver-to-spleen ratio (L/S ratio) according to computed tomography (CT) attenuation values, and the amount of visceral adipose tissue and subcutaneous adipose tissue by CT in 248 type 2 DM patients. We also investigated the relationship between the serum level of adiponectin and hepatic fibrosis. Results: Significant correlations were observed between the L/S ratios and aspartate aminotransferase, alanine aminotransferase, visceral adipose tissue, subcutaneous adipose tissue, and serum adiponectin values (r=0.300, p=0.0007), and there was a highly significant inverse correlation between the visceral adipose tissue values and the serum adiponectin levels (r=-0.327, p<0.0002). The subcutaneous adipose tissue values, however, were not correlated with the serum adiponectin levels. Multiple regression analysis was used to quantify the impact of measured variables on the L/S ratio. After adjustment for age, gender, and visceral adipose tissue, the serum adiponectin levels were still significantly correlated with the L/S ratios (p=0.0064). And there was a stepwise decrease in the serum adiponectin in parallel to the severity of hepatic fibrosis. Conclusions: Hypoadiponectinemia is concluded to be involved in the etiology of hepatic steatosis independently of visceral adipose tissue content, and is considered to be an important factor in the progression of fibrosis; further studies will be necessary to elucidate the exact physiological role of adiponectin and its contribution to the progression of NASH.

Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Publishing Authors By Initials

M Yoneda,T Iwasaki,K Fujita,H Kirikoshi,M Inamori,Y Nozaki,S Maeyama,K Wada,S Saito,Y Terauchi,A Nakajima,M Yoneda,T Iwasaki,K Fujita,H Kirikoshi,M Inamori,Y Nozaki,S Maeyama,K Wada,S Saito,Y Terauchi,A Nakajima,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Alcoholism, clinical and experimental research

VOLUME: 31

Page Numbers: S15-21

Journal Abbreviation: Alcohol. Clin. Exp. Res.

ISSN: 0145-6008

DAY: 2

MONTH: Jan

YEAR: 2007

Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707242

Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue.

AFFILIATION: Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Alcohol Clin Exp Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue Related Publications

• 2-epi-botcinin A and 3-O-acetylbotcineric acid from Botrytis cinerea.
• Acute pericarditis in the recovery phase of transient left ventricular apical ballooning syndrome (takotsubo cardiomyopathy).
• Adhesive papillae on the brachiolar arms of brachiolaria larvae in two starfishes, Asterina pectinifera and Asterias amurensis, are sensors for metamorphic inducing factor(s).
• Appropriate diameter for screws to fix the maxilla following Le Fort I osteotomy: an investigation utilizing finite element analysis.
• Bioactivity of CaSiO3/poly-lactic acid (PLA) composites prepared by various surface loading methods of CaSiO3 powder.
• Cardiovascular response to low-intensity walking with restricted leg muscle blood flow: 2334: board #13 june 1 3:30 PM -5:00 PM.
• Color auto-fluorescence from cancer lesions: improved detection of central type lung cancer.
• Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism.
• Efficient sum-frequency mixing through transparency induced by autoionization.
• Functional role for redox in the epileptogenesis: molecular regulation of glutamate in the hippocampus of FeCl3-induced limbic epilepsy model.
• Heart myofibrillogenesis occurs in isolated chick posterior blastoderm: a culture model.
• Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients.
• Human CYP2A6 is induced by estrogen via estrogen receptor.
• Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue.
• Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis.
• Importance of peroxisome proliferator-activated receptor-gamma in hepatic ischemia/reperfusion injury in mice.
• In vivo activation of N-methyl-d-aspartate receptors generates free radicals and reduces antioxidant ability in the rat hippocampus: Experimental protocol of in vivo ESR spectroscopy and microdialysis for redox status evaluation.
• Indoor air pollution and its impact on children under five years old in Bangladesh.
• Investigation of ultrafast nuclear spin polarization induced by short laser pulses.
• Large-scale correlation of DNA accession numbers to the cDNAs in the FANTOM full-length mouse cDNA clone set.
• Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies.
• Mass spectrometry and photoelectron spectroscopy of tetracene cluster anions, (tetracene)n- (n = 1-100): evidence for the highly localized nature of polarization in a cluster analogue of oligoacene crystals.
• Multistage approach for tracheobronchomalacia caused by a chest deformity in the setting of severe scoliosis.
• Non-contact Breath Motion Monitor ing System in Full Automation.
• Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C.
• Smoking behavior and related cancers: The role of CYP2A6 polymorphisms.
• Stress distribution on the thorax after the Nuss procedure for pectus excavatum results in different patterns between adult and child patients.
• Telmisartan, An Angiotensin II Type 1 Receptor Blocker, Controls Progress of Nonalcoholic Steatohepatitis in Rats.
• [A case of Behçet's disease with frequent recurrence of multiple pulmonary abscess-like opacities]
• [Pleomorphic ventricular tachycardia]