Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function.

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Abstract Text:

Ravi S Radhakrishnan,Hari R Radhakrishnan,Hasen Xue,Stacey D Moore-Olufemi,Anshu B Mathur,Norman W Weisbrodt,Frederick A Moore,Steven J Allen,Glen A Laine,Charles S Cox,

INTRODUCTION: Acute edema induced by resuscitation and mesenteric venous hypertension impairs intestinal transit and contractility and reduces intestinal stiffness. Pretreatment with hypertonic saline (HS) can prevent these changes. Changes in tissue stiffness have been shown to trigger signaling cascades via stress fiber formation. We proposed that acute intestinal edema leads to a decrease in intestinal transit that may be mediated by changes in stiffness, leading to stress fiber formation and decreased intestinal transit. Furthermore, HS administration will abolish these detrimental effects of edema. RESULTS: Intestinal edema causes a significant increase in tissue water and a significant decrease in intestinal transit and stiffness compared with sham. HS reversed these changes to sham levels. In addition, tissue edema led to significant stress fiber formation and decreased numbers of focal contacts. HS preserved tissue stiffness, prevented stress fiber formation, and was associated with improved intestinal function. CONCLUSION: HS eliminates intestinal tissue edema formation and improves intestinal transit. In addition, the action of HS may be mediated through its preservation of tissue stiffness, which leads to prevention of signaling via stress fiber formation, leading to preserved intestinal function. Finally, intestinal edema may provide a novel physiologic model for examining stiffness and stress fiber signaling.

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Publishing Authors By Initials

RS Radhakrishnan,HR Radhakrishnan,H Xue,SD Moore-Olufemi,AB Mathur,NW Weisbrodt,FA Moore,SJ Allen,GA Laine,CS Cox,

For similar pharmaceutical preparations: solutions: hypertonic solutions: saline solution, hypertonic research abstracts see: pharmaceutical preparations: solutions: hypertonic solutions: saline solution, hypertonic research

PUBMED ID PMID:

MEDLINE DATE:

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Critical care medicine

VOLUME: 35

Page Numbers: 538-43

Journal Abbreviation: Crit. Care Med.

ISSN: 0090-3493

DAY: 3

MONTH: Feb

YEAR: 2007

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 355501

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Keywords Mesh Terms:

KEYWORDS: Saline Solution, Hypertonic

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Information

Substance Name: Saline Solution, Hypertonic

Registry Number: 0

Grant and Affiliation Information for Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function.

AFFILIATION: Department of Surgery, University of Texas-Houston Medical School, Houston, TX, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32 GM08792

ACRONYM: GM

MEDLINETA: Crit Care Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function Related Publications

• Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice.
• Affinity purification of seminalplasmin and characterization of its interaction with calmodulin.
• Australian parasitological research: now and in 2000.
• CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection.
• Cancer and the threat of death: the cognitive dynamics of death-thought suppression and its impact on behavioral health intentions.
• Chapter 7: Achievements and limitations of cervical cytology screening.
• Costs of alcohol and drug-involved crime.
• Determination of ciglitazone in dog plasma by reversed-phase high-performance liquid chromatography.
• Effects of adult aging and hearing loss on comprehension of rapid speech varying in syntactic complexity.
• European psychiatry: moving towards integration and harmony.
• Experimental apparatus for the study of photoabsorption processes of multiply charged ions by synchrotron radiation.
• Genetic studies of stuttering in a founder population.
• Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function.
• Immune effector mechanisms in parasitic infections.
• Measurement of intestinal edema using an impedance analyzer circuit.
• Metabotropic glutamate receptors differentially regulate GABAergic inhibition in thalamus.
• Microcalorimetric investigation of the interaction of calmodulin with seminalplasmin and myosin light chain kinase.
• Modulation of thalamic neuron excitability by orexins.
• News from the WPA Secretariat.
• Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway.
• Only time can tell: unethical research and the passage of time.
• Organized unidirectional waves of ATP hydrolysis within a RecA filament.
• Prenatal methyl mercury exposure from fish consumption and child development: a review of evidence and perspectives from the Seychelles Child Development Study.
• Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.
• Role of the vitamin D receptor in hair follicle biology.
• Studies of pituitary-adrenal-testis interaction in sheep. II. The effects of repeated injections of adrenocorticotrophic hormone outside the breeding season.
• The 12th world congress of psychiatry.
• The 13th World Congress of Psychiatry, Cairo 2005: perspectives from the Secretariat.
• Use of retrovirus expression of interfering RNA to determine the contribution of activated k-ras and ras effector expression to human tumor cell growth.
• Using inhibitors of prenylation to block localization and transforming activity.