Hyperthermia and chemotherapy: preclinical considerations.

Hyperthermia and chemotherapy: preclinical considerations. Research Abstract Details 

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Hyperthermia and chemotherapy: preclinical considerations. Abstract Text:

D L Kisner,B J Lewis,

Malignant cells appear to be selectively sensitive to thermal injury. The precise mechanism of cell death after thermal exposure has not been established, but the phenomenon has been demonstrated by both in vitro and in vivo techniques. Synergy of hyperthermia and chemotherapy has been demonstrated for several agents, but in vitro results are not uniformly confirmed in vivo. In some agents (methyl-CCNU) no synergy was found in vivo. In others (adriamycin) synergy was only demonstrated at drug doses with intolerable toxicity. Studies of the effects of hyperthermia on drug pharmacokinetics are desirable for future clinical trial design.

Hyperthermia and chemotherapy: preclinical considerations. Publishing Authors By Initials

DL Kisner,BJ Lewis,

For similar organic chemicals: nitroso compounds: nitrosourea compounds research abstracts see: organic chemicals: nitroso compounds: nitrosourea compounds research

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Hyperthermia and chemotherapy: preclinical considerations. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 74

Page Numbers: 285-92

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1980

Hyperthermia and chemotherapy: preclinical considerations. Information

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LANGUAGE: eng

NlmUniqueID: 44671

Hyperthermia and chemotherapy: preclinical considerations. Keywords Mesh Terms:

KEYWORDS: Nitrosourea Compounds

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Hyperthermia and chemotherapy: preclinical considerations. Information

Substance Name: Nitrosourea Compounds

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Country: GERMANY, WEST

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MEDLINETA: Recent Results Cancer Res

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