Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease.

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Abstract Text:

Kelly Claire Simon,Honglei Chen,Michael Schwarzschild,Alberto Ascherio,

OBJECTIVE: To determine whether history of hypertension, hypercholesterolemia, or diabetes is associated with risk of Parkinson disease (PD). METHODS: Prospective study among participants in two large cohorts: the Nurses' Health Study (121,046 women) and the Health Professionals Follow-up Study (50,833 men). Mean duration of follow-up was 22.9 years in women, aged 30 to 55 years at baseline, and 12.6 years in men, aged 40 to 75 years at baseline. Relative risks (RRs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. RESULTS: We identified a total of 530 incident cases of PD during the follow-up. Risk of PD was not associated with self-reported history of hypertension (RR = 0.96, 95% CI = 0.80 to 1.15), high cholesterol (RR = 0.98, 95% CI = 0.82 to 1.19), or diabetes (RR = 1.04, 95% CI = 0.74 to 1.46), after adjusting for age and smoking in pack-years. Risk of PD decreased modestly with increasing levels of self-reported total cholesterol (RR for a 50-mg/dL increase in total cholesterol = 0.86, 95% CI = 0.78 to 0.95, p for trend = 0.02), but use of cholesterol-lowering drugs was not associated with PD risk (RR comparing users with nonusers = 0.85, 95% CI = 0.59 to 1.23). Among individuals with PD, systolic blood pressure was similar to noncases up to the time of diagnosis but declined afterward. CONCLUSIONS: Results of this large prospective study suggest that Parkinson disease risk is not significantly related to history of hypertension, hypercholesterolemia, or diabetes but may modestly decline with increasing blood cholesterol levels.

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Publishing Authors By Initials

KC Simon,H Chen,M Schwarzschild,A Ascherio,

For similar behavior and behavior mechanisms: behavior: habits: smoking research abstracts see: behavior and behavior mechanisms: behavior: habits: smoking research

PUBMED ID PMID:

MEDLINE DATE:

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Neurology

VOLUME: 69

Page Numbers: 1688-95

Journal Abbreviation: Neurology

ISSN: 1526-632X

DAY: 29

MONTH: 08

YEAR: 2007

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401060

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Keywords Mesh Terms:

KEYWORDS: Smoking

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease.

AFFILIATION: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. ksimon@hsph.harvard.edu

Country: United States

AGENCY: United States NIEHS

GRANT: T32 ES07069-26

ACRONYM: ES

MEDLINETA: Neurology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease Related Publications

• Allergy, family history of autoimmune diseases, and the risk of multiple sclerosis.
• Consumption of dairy products and risk of Parkinson's disease.
• Detection of pulmonary tuberculosis in Chiapas, Mexico.
• Diet and amyotrophic lateral sclerosis.
• Diet, urate, and Parkinson's disease risk in men.
• Epstein-Barr virus in the development of multiple sclerosis.
• Erectile function and risk of Parkinson's disease.
• Familial aggregation of Parkinson's disease: a meta-analysis.
• Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease.
• Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women.
• Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.
• Myelin oligodendrocyte glycoprotein antibodies and multiple sclerosis in healthy young adults.
• Perceived imbalance and risk of Parkinson's disease.
• Peripheral inflammatory biomarkers and risk of Parkinson's disease.
• Plasma titers of antibodies against Epstein-Barr virus BZLF1 and risk of multiple sclerosis.
• Plasma urate and risk of Parkinson's disease.
• Prospective study of dietary pattern and risk of Parkinson disease.
• Recreational physical activity and risk of Parkinson's disease.
• Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis.
• Smoking and cognitive function in Parkinson's disease.
• Telomere length and risk of Parkinson's disease.
• Temporal relationship between cigarette smoking and risk of Parkinson disease.
• Variation in the Epstein-Barr virus receptor, CR2, and risk of multiple sclerosis.
• Variations in gender ratios support the connection between smoking and Parkinson's disease.