Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3.

Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Research Abstract Details 

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Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Abstract Text:

Bernadette P Cabigas,Jidong Su,William Hutchins,Yang Shi,Richard B Schaefer, Recinos,Vani Nilakantan,Eric Kindwall,Jeffrey A Niezgoda,John E Baker,

OBJECTIVE: The relative contributions of the fraction of inspired oxygen (FIO2) and atmospheric pressure (ATM) to cardioprotection are unknown. We determined whether the product of FIO2 x ATM (oxygen partial pressure) controls the extent of hyperoxic+hyperbaric-induced cardioprotection and involves activation of nitric oxide synthase (NOS). METHODS: Adult Sprague Dawley rats (n = 10/gp) were treated for 1 h with (1) normoxia+normobaria (21% O2 at 1 ATM), (2) hyperoxia+normobaria (100% O2 at 1 ATM), (3) normoxia+hyperbaria (21% O2 at 2 ATM) and (4) hyperoxia+hyperbaria (100% O2 at 2 ATM). RESULTS: Infarct size following 25 min ischemia and 180 min reperfusion was decreased following hyperoxia+normobaria and normoxia+hyperbaria compared with normoxia+normobaria and further decreased following hyperoxia+hyperbaria treatment. l-NAME (200 microM) reversed the cardioprotective effects of hyperoxia+hyperbaria. Nitrite plus nitrate content was increased 2.2-fold in rats treated with normoxia+hyperbaria and hyperoxia+hyperbaria. NOS3 protein increased 1.2-fold and association of hsp90 with NOS3 four-fold in hyperoxic+hyperbaric rats. CONCLUSIONS: Cardioprotection conferred by hyperoxia+hyperbaria is directly dependent on oxygen availability and mediated by NOS.

Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Publishing Authors By Initials

BP Cabigas,J Su,W Hutchins,Y Shi,RB Schaefer,RF Recinos,V Nilakantan,E Kindwall,JA Niezgoda,JE Baker,

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Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cardiovascular research

VOLUME: 72

Page Numbers: 143-51

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ISSN: 0008-6363

DAY: 21

MONTH: 07

YEAR: 2006

Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Information

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LANGUAGE: eng

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AFFILIATION: Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA. bgcab@yahoo.com

Country: Netherlands

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MEDLINETA: Cardiovasc Res

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