Hydroxyurea chemotherapy in the treatment of meningiomas.

Hydroxyurea chemotherapy in the treatment of meningiomas. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hydroxyurea chemotherapy in the treatment of meningiomas. Abstract Text:

Herbert B Newton,Herbert B Newton,

Meningiomas are slow growing, extraaxial tumors that derive from the arachnoidal cap cells of the meninges. Resection remains the main modality of treatment and can be curative in some cases. External-beam radiotherapy and radiosurgery can benefit selected patients. The role of chemotherapy continues to be defined, but should be considered for patients with inoperable or frequently recurring meningiomas. Hydroxyurea, an inhibitor of ribonucleotide reductase, is one of the most active agents and is known to induce apoptosis in meningioma cells in vitro and in mouse xenografts. Results of preliminary clinical studies suggest that hydroxyurea has modest activity against recurrent and inoperable meningiomas, and can induce long term stabilization in some patients. However, the results are conflicting and a few clinical trials did not show positive results. Further clinical trials with larger patient cohorts and longer follow-up periods will be necessary to confirm the activity of hydroxyurea.

Hydroxyurea chemotherapy in the treatment of meningiomas. Publishing Authors By Initials

HB Newton,HB Newton,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Hydroxyurea chemotherapy in the treatment of meningiomas. Journal Published:

PUBLICATION TYPE: Review

Journal: Neurosurgical focus

VOLUME: 23

Page Numbers: E11

Journal Abbreviation:

ISSN: 1092-0684

DAY: 26

MONTH: 10

YEAR: 2007

Hydroxyurea chemotherapy in the treatment of meningiomas. Information

Number of References: 65

LANGUAGE: eng

NlmUniqueID: 100896471

Hydroxyurea chemotherapy in the treatment of meningiomas. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Hydroxyurea chemotherapy in the treatment of meningiomas. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hydroxyurea chemotherapy in the treatment of meningiomas.

AFFILIATION: Dardinger Neuro-Oncology Center and Division of Neuro-Oncology, Department of Neurology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA. newton.2@osu.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neurosurg Focus

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hydroxyurea chemotherapy in the treatment of meningiomas Related Publications

• Advances in strategies to improve drug delivery to brain tumors.
• Amplitude Control of Protein Kinase C by RINCK, a Novel E3 Ubiquitin Ligase.
• Anterior and thoracoscopic scoliosis surgery for idiopathic scoliosis.
• Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos).
• Comparisons among two fertile and three male-sterile mitochondrial genomes of maize.
• Conformations generated during turnover of the Azotobacter vinelandii nitrogenase MoFe protein and their relationship to physiological function.
• Electrophile-directed diastereoselective alkylation of prochiral enediolates.
• Epigenetic marking and neuronal plasticity.
• Explaining inappropriate strategy selection in a simple reasoning task.
• Further thoughts on the eradication of strangles in equids.
• GOTYS - Getting Older, Thinking Younger.
• How gaming is used as an innovative strategy for nursing education.
• Hydroxyurea chemotherapy in the treatment of meningiomas.
• Layer guided-acoustic plate mode biosensors for monitoring MHC-peptide interactions.
• Leveraging latent information in NMR spectra for robust predictive models.
• MDMA use and neurocognition: a meta-analytic review.
• Mechanisms of solute transport through outer membrane porins: burning down the house.
• Oral health acculturation in Albanian-speakers in south London.
• Oxygen depletion in relation to water residence times.
• Pathological gamblers demonstrate frontal lobe impairment consistent with that of methamphetamine-dependent individuals.
• Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
• Prospective study to determine accuracy of rapid serological assays for diagnosis of acute dengue virus infection in laos.
• Proteomic analysis identifies oxidative stress induction by adaphostin.
• Putting evidence into practice: does the workplace really matter?
• Risk factors for influenza infection in vaccinated racehorses: lessons from an outbreak in Newmarket, UK in 2003.
• Subjective and cardiovascular effects of cocaine during treatment with amantadine and baclofen in combination.
• The healing forearm fracture: a matched comparison of forearm refractures.
• The influence of personality on patients' satisfaction with existing and new complete dentures.
• The psychology of failure for dentists.
• The supercentenarians and how to get the most out of life.