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Hydrolyzed casein influences intestinal mucin gene expression in the rat.

Hydrolyzed casein influences intestinal mucin gene expression in the rat. Research Abstract Details 

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  • Hydrolyzed casein influences intestinal mucin gene expression in the rat. Abstract Text:

    The effect of hydrolyzed casein (HC) on the expression of three mucin genes (Muc2, Muc3, and Muc4) in the rat intestine was investigated using quantitative real-time polymerase chain reaction. After a 10 day acclimatization period, rats received for 8 days the test diets containing either HC or a synthetic amino acid (SAA) mixture as the sole source of nitrogen or a protein-free (PF) diet (n = 12 per treatment). The addition of HC or the SAA mixture to the diet significantly improved average daily gain, average daily food intake, and gain:feed ratio as compared with the PF diet. Terminal ileal endogenous N flow was significantly higher for the HC-fed rats in comparison with either the SAA or the PF rats (p < or = 0.001). HC supported a significant increase of Muc3 mRNA (277 and 229% of that for diets PF and SAA, respectively; p < or = 0.05) in the small intestinal tissue and Muc4 mRNA (325 and 265% of that for diets PF and SAA, respectively; p < or = 0.05) in the colon. In conclusion, HC enhances ileal endogenous N flow and up-regulates in vivo the expression of some individual mucin genes.

    Hydrolyzed casein influences intestinal mucin gene expression in the rat. Publishing Authors By Initials

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    Hydrolyzed casein influences intestinal mucin gene expression in the rat. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of agricultural and food chemistry

    VOLUME: 56

    Page Numbers: 5572-6

    Journal Abbreviation: J. Agric. Food Chem.

    ISSN: 1520-5118

    DAY: 18

    MONTH: 06

    YEAR: 2008

    Hydrolyzed casein influences intestinal mucin gene expression in the rat. Information

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    LANGUAGE: eng

    NlmUniqueID: 374755

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    Grant and Affiliation Information for Hydrolyzed casein influences intestinal mucin gene expression in the rat.

    AFFILIATION: Riddet Institute, Massey University, Private Bag 11 222, Palmerston North, New Zealand.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: J Agric Food Chem

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