Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO).

Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). Abstract Text:

Xin Sha,T Scott Isbell,Rakesh P Patel,Cynthia S Day,S Bruce King,

Nitroxyl (HNO/NO(-)), the reduced form of nitric oxide, has gained attention based on its separate chemistry and biology from nitric oxide. The inherent reactivity of HNO requires new and mechanistically unique donors for the detailed study of HNO chemistry and biology. Oxidation of cyclohexanone oxime with lead tetraacetate yields 1-nitrosocyclohexyl acetate, whereas oxidation of oximes in the presence of excess carboxylic acid gives various acyloxy nitroso compounds. These bright blue compounds exist as monomers as indicated by their infrared, proton, and carbon NMR spectra, and X-ray crystallographic analysis reveals the nitroso groups possess a "nitroxyl-like" bent configuration. Hydrolysis of these compounds produces nitrous oxide, the dimerization and dehydration product of HNO, and provides evidence for the intermediacy of HNO. Both thiols and oxidative metal complexes inhibit nitrous oxide formation. Hydrolysis of these compounds in the presence of ferric heme complexes forms ferrous nitrosyl complexes providing further evidence for the intermediacy of HNO. Kinetic analysis shows that the rate of hydrolysis depends on pH and the structure of the acyl group of the acyloxy nitroso compound. These compounds relax pre-constricted rat aortic rings similar to known HNO donors. Together, these results identify acyloxy nitroso compounds as a new class of HNO donors.

Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). Publishing Authors By Initials

X Sha,TS Isbell,RP Patel,CS Day,SB King,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 9687-92

Journal Abbreviation:

ISSN: 0002-7863

DAY: 2

MONTH: Aug

YEAR: 2006

Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO).

AFFILIATION: Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Chem Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hydrolysis of acyloxy nitroso compounds yields nitroxyl HNO Related Publications

• A satisfaction enhancement intervention for long-term weight loss.
• A systematic literature review of tobacco use among adults 15 years and older in sub-Saharan Africa.
• Coloring our eyes.
• Computational study of the contribution of the vasculature on the dynamic response of the brain.
• Cytogenetic analysis of Day-4 embryos from PMSG/hCG-treated prepuberal gilts.
• Death by survey: estimating adult mortality without selection bias from sibling survival data.
• Dynamic regulation of single- and mixed-species malaria infection: insights to specific and non-specific mechanisms of control.
• Early recurrence of an intracranial epidermoid cyst due to low-grade infection: case report.
• Factors that shape young people's sexual behaviour: a systematic review.
• Glutamine deamidation destabilizes human gammaD-crystallin and lowers the kinetic barrier to unfolding.
• Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO).
• Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and management.
• Impacting policy through science and education.
• Incorporation of system resolution compensation (RC) in the ordered-subset transmission (OSTR) algorithm for transmission imaging in SPECT.
• Mechanical characterization of porcine abdominal organs.
• Morphological study of the bovine blastocyst with phase contrast microscopy.
• Prenatal malaria immune experience affects acquisition of Plasmodium falciparum merozoite surface protein-1 invasion inhibitory antibodies during infancy.
• Progesterone and luteinizing hormone profiles in heifers used as oocyte donors.
• Reduction in antimicrobial substantivity of MTAD after initial sodium hypochlorite irrigation.
• Regio- and stereospecific syntheses and nitric oxide donor properties of (E)-9- and (E)-10-nitrooctadec-9-enoic acids.
• Reproductive performance of Polwarth and corriedale sheep in Tasmania.
• Simultaneous assessment of cardiac perfusion and function using 5-dimensional imaging with Tc-99m teboroxime.
• Streptomycin and dihydrostreptomycin; applied pharmacology.
• Stress versus discrete negative emotions in the prediction of physical complaints: does predictive utility vary across ethnic groups?
• Structural Response of Lower Leg Muscles in Compression: A Low Impact Energy Study Employing Volunteers, Cadavers and the Hybrid III.
• The impact of group size on memory and memory beliefs: a methodological report.
• The importance of drug delivery to optimize the effects of bone morphogenetic proteins during periodontal regeneration.
• Tourette syndrome: the self under siege.
• Use of three-dimensional Gaussian interpolation in the projector/backprojector pair of iterative reconstruction for compensation of known rigid-body motion in SPECT.
• Vitamin E inhibits melanoma growth in mice.