Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism.

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Abstract Text:

Mammalian cells responds to physical forces by altering their growth rate, morphology, metabolism, and genetic expression. We have studied the mechanism by which these cells detect the presence of mechanical stress and convert this force into intracellular signals. As our model systems, we have studied cultured human endothelial cells, which line the blood vessels and forms the interface between the blood and the vessel wall. These cell responds within minutes to the initiation of flow by increasing their arachidonic acid metabolism and increasing the level of the intracellular second messengers inositol trisphosphate and calcium ion concentration. With continued exposure to arterial levels of wall shear stress for up to 24 h, endothelial cells increase the expression of tissue plasminogen activator (tPA) and tPA messenger RNA (mRNA) and decrease the expression of endothelin peptide and endothelin mRNA. Since the initiation of flow also causes enhanced convective mass transfer to the endothelial cell monolayer, we have investigated the role of enhanced convection of adenosine trisphosphate (ATP) to the cell surface in eliciting a cellular response by monitoring cytosolic calcium concentrations on the single cell level and by computing the concentration profile of ATP in a parallel-plate flow geometry. Our result demonstrate that endothelial cells respond in very specific ways to the initiation of flow and that mass transfer and fluid shear stress can both play a role in the modulation of intracellular signal transduction and metabolism.

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biotechnology and bioengineering

VOLUME: 38

Page Numbers: 588-602

Journal Abbreviation: Biotechnol. Bioeng.

ISSN: 0006-3592

DAY: 8

MONTH: Sep

YEAR: 1991

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7502021

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism.

AFFILIATION: Cox Laboratory of Biomedical Engineering, Institute of Biosciences and Bioengineering, Rice University, Houston, Texas 77251-1892.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biotechnol Bioeng

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism Related Publications

• America needs the older handicapped worker.
• Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow.
• Cyclic strain and motion control produce opposite oxidative responses in two human endothelial cell types.
• Enhanced platelet adhesion and aggregation by endothelial cell-derived unusually large multimers of von Willebrand factor.
• For now and the future.
• Gene Expression of Endothelial Cells due to Interleukin-1 Beta Stimulation and Neutrophil Transmigration.
• Gene expression of endothelial cells under pulsatile non-reversing vs. steady shear stress; comparison of nitric oxide production.
• HIV transmission during invasive radiologic procedures: estimate based on computer modeling.
• Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism.
• Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.
• Needle-stick injuries and blood contacts during invasive radiologic procedures: frequency and risk factors.
• Oxidative stress produced with cell migration increases synthetic phenotype of vascular smooth muscle cells.
• Treatment of metal-contaminated water using bacterial sulfate reduction: Results from pilot-scale reactors.