Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema.

Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Research Abstract Details 

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Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Abstract Text:

James C Parker,

Recent permeability studies comparing endothelial cell phenotypes derived from alveolar and extra-alveolar vessels have significant implications for interpreting the mechanisms of fluid homeostasis in the intact lung. These studies indicate that confluent monolayers of rat pulmonary microvascular endothelial cells had a hydraulic conductance (L(p)) that was only 5% and a transendothelial flux rate for 72-kDa dextran only 9% of values determined for rat pulmonary artery endothelial cell monolayers. On the basis of previous studies partitioning the filtration coefficients between alveolar and extra-alveolar vascular segments in rat lungs and previous studies of lymph albumin fluxes and permeability, the contribution of the alveolar capillary segment to total albumin flux in lymph was estimated to be less than 10%. In addition, the Starling safety factors against the edema calculated for the alveolar capillaries are quite different from those estimated for whole lung. Estimates of the edema safety factor due to increased filtration across the alveolar capillary wall based on the low L(p) indicate it is quantitatively the greatest safety factor, although it would be a minor safety factor for extra-alveolar vessels. Also, a markedly higher effective protein osmotic absorptive force for plasma proteins must occur in the capillaries relative to extra-alveolar vessels. The lower L(p) for alveolar capillaries also has implications for the sequence of hydrostatic edema formation, and it also may have a role in preventing exercise-induced alveolar flooding.

Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Publishing Authors By Initials

JC Parker,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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MEDLINE DATE:

Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Lung cellular and

VOLUME: 292

Page Numbers: L378-80

Journal Abbreviation: Am. J. Physiol. Lung Cell Mol.

ISSN: 1040-0605

DAY: 13

MONTH: 10

YEAR: 2006

Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Information

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LANGUAGE: eng

NlmUniqueID: 100901229

Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Information

Substance Name: Albumins

Registry Number: 0

Grant and Affiliation Information for Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema.

AFFILIATION: Department of Physiology, College of Medicine, University of South Alabama, 307 University Blvd., Mobile, AL 36688, USA. jparker@usouthal.edu

Country: United States

AGENCY: United States NHLBI

GRANT: P01-HL-66299

ACRONYM: HL

MEDLINETA: Am J Physiol Lung Cell Mol Phy

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