Humic substances modify accumulation but not biotransformation of pyrene in salmon yolk-sac fry.

Humic substances modify accumulation but not biotransformation of pyrene in salmon yolk-sac fry. Research Abstract Details 

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Humic substances modify accumulation but not biotransformation of pyrene in salmon yolk-sac fry. Abstract Text:

J O Honkanen,C Wiegand,J V K Kukkonen,

Humic substances may influence the bioavailability of polycyclic aromatic hydrocarbons (PAHs) in aquatic environment. Relatively little is known how humic substances affect the biotransformation of PAHs in aquatic animals. Here we report how two different types of humic substances affected the accumulation of pyrene, a four-ringed PAH, to yolk-sac fry of landlocked salmon (Salmo salar m. sebago). The accumulation of pyrene to yolk-sac fry tissues was inversely related to humic substance concentration in a short term (72h) exposure. However, the biotransformation of pyrene was not affected by humic substances. Pyrene or humic subtances did not induce CYP1A activity in yolk-sac fry tissues contrasting to beta-naphthoflavone, which was used as a positive control. Yolk-sac fry were capable to biotransform pyrene to phase I (1-hydroxypyrene) and phase II (pyrene-1-sulphate) products. Interestingly, glucuronide conjugate (i.e. pyrene-1-glucuronide) was not present in yolk-sac fry tissues. The concentration of parent pyrene and 1-hydroxypyrene remained the same throughout the experiment but the concentration of pyrene-1-sulphate more than doubled from 24 to 72h. This finding suggests that salmon yolk-sac fry are not capable to excrete phase II biotransformation products or the excretion is very slow. Further, this could indicate that early life stage toxicity of many CYP1A inducing compounds is related to accumulation of phase II conjugates in fry tissues.

Humic substances modify accumulation but not biotransformation of pyrene in salmon yolk-sac fry. Publishing Authors By Initials

JO Honkanen,C Wiegand,JV Kukkonen,

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Humic substances modify accumulation but not biotransformation of pyrene in salmon yolk-sac fry. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Aquatic toxicology (Amsterdam, Netherlands)

VOLUME: 86

Page Numbers: 239-48

Journal Abbreviation: Aquat. Toxicol.

ISSN: 0166-445X

DAY: 12

MONTH: 11

YEAR: 2007

Humic substances modify accumulation but not biotransformation of pyrene in salmon yolk-sac fry. Information

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LANGUAGE: eng

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AFFILIATION: Laboratory of Aquatic Ecology and Ecotoxicology, Faculty of Biosciences, University of Joensuu, Finland.

Country: Netherlands

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MEDLINETA: Aquat Toxicol

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