Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.

Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. Research Abstract Details 

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Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. Abstract Text:

Yesu Jeon,Kyung Yong Lee,Min Ji Ko,Yong Sun Lee,Sukhyun Kang,Deog Su Hwang,

Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we show that TopBP1 is also required for G(1) to S progression in a normal cell cycle. TopBP1 deficiency inhibited cells from entering S phase by up-regulating p21 and p27, resulting in down-regulation of cyclin E/CDK2. Although co-depletion of p21 and p27 with TopBP1 restored the cyclin E/CDK2 kinase activity, however, cells remained arrested at the G(1)/S boundary, showing defective chromatin-loading of replication components. Based on these results, we suggest a dual role of TopBP1 necessary for the G(1)/S transition: one for activating cyclin E/CDK2 kinase and the other for loading replication components onto chromatin to initiate DNA synthesis.

Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. Publishing Authors By Initials

Y Jeon,KY Lee,MJ Ko,YS Lee,S Kang,DS Hwang,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: p21-activated kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: p21-activated kinases research

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Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 14882-90

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 10

MONTH: 02

YEAR: 2007

Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. Keywords Mesh Terms:

KEYWORDS: p21-Activated Kinases

MESH TERMS: physiology

Chemical & Substance for Abstract: Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. Information

Substance Name: p21-Activated Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.

AFFILIATION: Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742, Korea.

Country: United States

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MEDLINETA: J Biol Chem

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