Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-X(L) expression.

Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-X(L) expression. Research Abstract Details 

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Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-X(L) expression. Abstract Text:

Z Wang,B Spittau,M Behrendt,B Peters,K Krieglstein,

TGF-beta-induced apoptosis is essential for embryonic development and mainteanance of adult tissues. Impairment of the apoptotic pathway, regulated by TGF-beta, plays a center role in tumorigenesis and manifestations of different diseases. TIEG2/KLF11 is a recently identified human TGF-beta-inducible zinc finger protein belonging to the family of Sp1/KLF-like transcription factors. In human and murine tissues it has been shown that TIEG1 and TIEG2 induce apoptosis and inhibit cell growth. Since TGF-beta and Tieg1 are able to induce apoptosis in the oligodendroglial cell line OLI-neu, we analysed the ability of TIEG2 to mimic the effects observed after treatment with TGF-beta and overexpression of Tieg1. Herein we report that TIEG2 induces Caspase3-dependent apoptosis in murine OLI-neu cells. Furthermore, we could demonstrate that TIEG2 decreases the levels of the anti-apoptotic protein Bcl-X(L) and inhibits transcription driven by the Bcl-X(L) promoter. These data suggest that TIEG2 serves as a downstream mediator of TGF-beta, bridging TGF-beta-dependent signaling to the intracellular pathway of apoptosis.

Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-X(L) expression. Publishing Authors By Initials

Z Wang,B Spittau,M Behrendt,B Peters,K Krieglstein,

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Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-X(L) expression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neural transmission (Vienna, Austria :

VOLUME: 114

Page Numbers: 867-75

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ISSN: 0300-9564

DAY: 19

MONTH: 02

YEAR: 2007

Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-X(L) expression. Information

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LANGUAGE: eng

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AFFILIATION: Center of Anatomy, Department of Neuroanatomy, University of Goettingen, Goettingen, Germany.

Country: Austria

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MEDLINETA: J Neural Transm

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