Human thymus regeneration and T cell reconstitution.

Human thymus regeneration and T cell reconstitution. Research Abstract Details 

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Human thymus regeneration and T cell reconstitution. Abstract Text:

Nicolas Legrand,Wendy Dontje,Anja U van Lent,Hergen Spits,Bianca Blom,Nicolas Legrand,Wendy Dontje,Anja U van Lent,Hergen Spits,Bianca Blom,Nicolas Legrand,Wendy Dontje,Anja U van Lent,Hergen Spits,Bianca Blom,

The thymus supports the development of T cells throughout life from hematopoietic progenitor cells migrating from the bone marrow. During the early years after birth thymic activity is highest, but progressively declines resulting in diminished naïve T cell output. Underlying causes of thymic involution may be degeneration of the stromal thymic network, providing survival and differentiation factors for developing T cells, or insufficiency of the progenitor cells to home and/or develop in the aged thymus. In young people the reduced thymic output is insignificant, since the peripheral T cell compartment is under compensatory homeostatic control. However, in more or less immunocompromised individuals, including aged people and patients depleted of T cells due to conditioning regimens before bone marrow transplantation or HIV infection, the thymus is necessary to replenish the peripheral T cell compartment. This may require rejuvenation of the thymus. Alternatively, approaches to generate mature T cells independent of the thymus have gained considerable interest.

Human thymus regeneration and T cell reconstitution. Publishing Authors By Initials

N Legrand,W Dontje,AU van Lent,H Spits,B Blom,N Legrand,W Dontje,AU van Lent,H Spits,B Blom,N Legrand,W Dontje,AU van Lent,H Spits,B Blom,

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Human thymus regeneration and T cell reconstitution. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Seminars in immunology

VOLUME: 19

Page Numbers: 280-8

Journal Abbreviation: Semin. Immunol.

ISSN: 1044-5323

DAY: 9

MONTH: 11

YEAR: 2007

Human thymus regeneration and T cell reconstitution. Information

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LANGUAGE: eng

NlmUniqueID: 9009458

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Grant and Affiliation Information for Human thymus regeneration and T cell reconstitution.

AFFILIATION: Department of Cell Biology & Histology, Academic Medical Center at the University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

Country: England

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MEDLINETA: Semin Immunol

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