Human subtelomeric duplicon structure and organization.

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Human subtelomeric duplicon structure and organization. Abstract Text:

Anthony Ambrosini,Sheila Paul,Sufen Hu,Harold Riethman,Anthony Ambrosini,Sheila Paul,Sufen Hu,Harold Riethman,Anthony Ambrosini,Sheila Paul,Sufen Hu,Harold Riethman,

ABSTRACT : BACKGROUND : Human subtelomeric segmental duplications ('subtelomeric repeats') comprise about 25% of the most distal 500 kb and 80% of the most distal 100 kb in human DNA. A systematic analysis of the duplication substructure of human subtelomeric regions was done in order to develop a detailed understanding of subtelomeric sequence organization and a nucleotide sequence-level characterization of subtelomeric duplicon families. RESULTS : The extent of nucleotide sequence divergence within subtelomeric duplicon families varies considerably, as does the organization of duplicon blocks at subtelomere alleles. Subtelomeric internal (TTAGGG)n-like tracts occur at duplicon boundaries, suggesting their involvement in the generation of the complex sequence organization. Most duplicons have copies at both subtelomere and non-subtelomere locations, but a class of duplicon blocks is identified that are subtelomere-specific. In addition, a group of six subterminal duplicon families are identified that, together with six single-copy telomere-adjacent segments, include all of the (TTAGGG)n-adjacent sequence identified so far in the human genome. CONCLUSION : Identification of a class of duplicon blocks that is subtelomere-specific will facilitate high-resolution analysis of subtelomere repeat copy number variation as well as studies involving somatic subtelomere rearrangements. The significant levels of nucleotide sequence divergence within many duplicon families as well as the differential organization of duplicon blocks on subtelomere alleles may provide opportunities for allele-specific subtelomere marker development; this is especially true for subterminal regions, where divergence and organizational differences are the greatest. These subterminal sequence families comprise the immediate cis-elements for (TTAGGG)n tracts, and are prime candidates for subtelomeric sequences regulating telomere-specific (TTAGGG)n tract length in humans.

Human subtelomeric duplicon structure and organization. Publishing Authors By Initials

A Ambrosini,S Paul,S Hu,H Riethman,A Ambrosini,S Paul,S Hu,H Riethman,A Ambrosini,S Paul,S Hu,H Riethman,

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Human subtelomeric duplicon structure and organization. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genome biology

VOLUME: 8

Page Numbers: R151

Journal Abbreviation: Genome Biol.

ISSN: 1465-6914

DAY: 16

MONTH: 01

YEAR: 2007

Human subtelomeric duplicon structure and organization. Information

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LANGUAGE: eng

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AFFILIATION: The Wistar Institute, Spruce St, Philadelphia, PA 19104, USA. aambrosi@princeton.edu.

Country: England

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MEDLINETA: Genome Biol

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