Human papillomavirus in pterygium.

Human papillomavirus in pterygium. Research Abstract Details 

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Human papillomavirus in pterygium. Abstract Text:

AIM: To determine the prevalence and significance of human papillomaviral types in conjunctival pterygia. METHODS: Polymerase chain reaction technology was used to identify the presence of human papillomavirus (HPV) in 10 formalin fixed paraffin embedded pterygia samples. 10 conjunctival papillomas were used as positive controls. 20 conjunctival samples, 10 with primary acquired melanosis and 10 with malignant melanoma, were used as negative controls. Sample subgroups were of equal sex, race, and age distribution to eliminate bias. All samples were further analysed (for 21 HPV types) using dot-blot hybridisation techniques. RESULTS: HPV was identified in 90% of the conjunctival papillomas, 50% of the pterygia samples, but no HPV was detected in the negative control group. Two pterygia showed type 6, two type 11, and one type 16. These three HPV types were also detected in papillomas. CONCLUSION: These results suggest that HPV may be involved in the pathogenesis of pterygia and that broadly the same HPV types are found in pterygia and in papillomas. Persistent conjunctival HPV may possibly play a part in the recurrence of pterygia post excision but further larger studies are required to elucidate this hypothesis.

Human papillomavirus in pterygium. Publishing Authors By Initials

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Human papillomavirus in pterygium. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of ophthalmology

VOLUME: 85

Page Numbers: 782-4

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Jul

YEAR: 2001

Human papillomavirus in pterygium. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Human papillomavirus in pterygium. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: complications

Chemical & Substance for Abstract: Human papillomavirus in pterygium. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for Human papillomavirus in pterygium.

AFFILIATION: Arrow Park Hospital, Wirral, Liverpool, UK. mjgallagher@doctors.org.uk

Country: England

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MEDLINETA: Br J Ophthalmol

REFSOURCE: Br J Ophthalmol. 2003 Aug;87(8):1046-8

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