Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma.

Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma. Abstract Text:

S A Tonon,M A Picconi,J B Zinovich,D J Liotta,P D Bos,J A Galuppo,L V Alonio,J A Ferreras,A R ,

OBJECTIVE: To assess the prevalence and potential risk factors associated with human papillomavirus (HPV) cervical infection among women residing in a region of northeastern Argentina with a high incidence of cervical cancer. METHODS: A case-control study of 330 women participating in a cervical cytological screening program conducted in Posadas city, Misiones, Argentina, from February 1997 to November 1998 was carried out. Standardized questionnaires were administered, and clinical examination including colposcopy was performed. Fresh endocervical specimens for HPV DNA detection by generic polymerase chain reaction were collected and the products typed by dot-blot hybridization. RESULTS: Human papillomavirus DNA was found in 61% of samples analyzed (185/301). Samples with normal cytology had a 43% infection rate (85/199), while those classified as low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, and invasive cervical carcinoma had an infection rate of 96% (53/55), 100% (29/29), and 100% (18/18), respectively. Human papillomavirus typing showed a 64% (118/185) prevalence of type 16 among all the infected population analyzed; type 16 was detected among 49% (42/85) of infected samples with normal cytology and in an average of 74% (74/100) with abnormal cytology. Sexual behavior, residence in southern Paraguay, and history of a previous sexually transmitted diseases were the main risk factors associated with high-grade cervical lesions. CONCLUSIONS: An elevated prevalence of HPV infection was detected in this population, which also has a high incidence of cervical cancer. The broad distribution of high-risk HPV type 16 in women with normal cytology and colposcopy suggests that viral infection is an important determinant of regional cancer incidence.

Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma. Publishing Authors By Initials

SA Tonon,MA Picconi,JB Zinovich,DJ Liotta,PD Bos,JA Galuppo,LV Alonio,JA Ferreras,AR ,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Infectious diseases in obstetrics and gynecology

VOLUME: 7

Page Numbers: 237-43

Journal Abbreviation: Infect Dis Obstet Gynecol

ISSN: 1064-7449

DAY: 21

MONTH: 01

YEAR: 1999

Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9318481

Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma. Keywords Mesh Terms:

KEYWORDS: Uterine Cervical Neoplasms

MESH TERMS: virology

Chemical & Substance for Abstract: Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma.

AFFILIATION: Laboratorio de Biología Molecular Aplicada; Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones, Argentina. tonon@arnet.com.ar

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Infect Dis Obstet Gynecol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma Related Publications

• Bioaccumulation of heavy metals and radionuclides from seawater by encased embryos of the spotted dogfish Scyliorhinus canicula.
• Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma.
• Persistence of human papillomavirus DNA in cervical lesions after treatment with diathermic large loop excision.
• Spontaneous polymerization at the air-water interface: a brewster angle microscopy study.
• The Accumulation of Lead and Mercury from Seawater and Their Depuration by Eggs of the Spotted Dogfish Scyliorhinus canicula (Chondrichthys).