Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy.

Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy. Research Abstract Details 

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Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy. Abstract Text:

BACKGROUND: Oral psoralen with UV-A (PUVA) photochemotherapy is known to cause cutaneous malignancies and has been associated with cutaneous immunosuppression. Human papillomavirus infection has also been associated with cutaneous malignancies and with immunosuppressed individuals. We therefore sought evidence of human papillomavirus infection in a patient with a long history of PUVA therapy and multiple cutaneous malignancies. OBSERVATIONS: During a 15-year period, an otherwise healthy patient with psoriasis who had undergone a 10-year course of PUVA photochemotherapy developed 13 squamous cell carcinomas, eight lesions diagnosed as "squamous cell carcinoma vs keratoacanthoma," 14 other keratoacanthomas, six basal cell carcinomas, one melanoma in situ, and 18 other keratinocytic dysplasias. Twenty-two of the 30 lesions tested for human papillomavirus DNA by polymerase chain reaction were positive for type 16/18, including six of the seven basal or squamous cell carcinomas tested. CONCLUSION: We hypothesize that PUVA therapy-induced immunosuppression may play an important role in PUVA-related carcinogenesis by affecting the extent and pathogenicity of human papillomavirus infection.

Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy. Publishing Authors By Initials

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 131

Page Numbers: 701-4

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jun

YEAR: 1995

Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: pathology

Chemical & Substance for Abstract: Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy. Information

Substance Name: Psoralens

Registry Number: 0

Grant and Affiliation Information for Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy.

AFFILIATION: Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI, USA.

Country: UNITED STATES

AGENCY: United States PHS

GRANT: 49531

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MEDLINETA: Arch Dermatol

REFSOURCE: Arch Dermatol. 1996 Jan;132(1):90

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