Human Nod1 confers responsiveness to bacterial lipopolysaccharides.

Human Nod1 confers responsiveness to bacterial lipopolysaccharides. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Human Nod1 confers responsiveness to bacterial lipopolysaccharides. Abstract Text:

The immune response to microbial pathogens is initiated by recognition of specific pathogen components by host cells both at the cell surface and in the cytosol. While the response triggered by pathogen products at the surface of immune cells is well characterized, that initiated in the cytosol is poorly understood. Nod1 is a member of a growing family of intracellular proteins with structural homology to apoptosis regulators Apaf-1/Ced-4 and a class of plant disease-resistant gene products. Here we show that bacterial lipopolysaccharides, but not other pathogen components tested, induced TLR4- and MyD88-independent NF-kappaB activation in human embryonic kidney 293T cells expressing trace amounts of Nod1. Nod2, another Nod family member, also conferred responsiveness to bacterial components but with a response pattern different from that observed with Nod1. As it was reported for plant disease-resistant R proteins, the leucine-rich repeats of Nod1 and Nod2 were required for lipopolysaccharide-induced NF-kappaB activation. A lipopolysaccharide binding activity could be specifically coimmunopurified with Nod1 from cytosolic extracts. These observations suggest that Nod1 and Nod2 are mammalian counterparts of plant disease-resistant gene products that may function as cytosolic receptors for pathogen components derived from invading bacteria.

Human Nod1 confers responsiveness to bacterial lipopolysaccharides. Publishing Authors By Initials

For similar proteins: receptors, cytoplasmic and nuclear research abstracts see: proteins: receptors, cytoplasmic and nuclear research

PUBMED ID PMID:

MEDLINE DATE:

Human Nod1 confers responsiveness to bacterial lipopolysaccharides. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of biological chemistry

VOLUME: 276

Page Numbers: 2551-4

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 31

MONTH: 10

YEAR: 2000

Human Nod1 confers responsiveness to bacterial lipopolysaccharides. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Human Nod1 confers responsiveness to bacterial lipopolysaccharides. Keywords Mesh Terms:

KEYWORDS: Receptors, Cytoplasmic and Nuclear

MESH TERMS: metabolism

Chemical & Substance for Abstract: Human Nod1 confers responsiveness to bacterial lipopolysaccharides. Information

Substance Name: Receptors, Cytoplasmic and Nuclear

Registry Number: 0

Grant and Affiliation Information for Human Nod1 confers responsiveness to bacterial lipopolysaccharides.

AFFILIATION: Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor 48109, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA64556

ACRONYM: CA

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Human Nod1 confers responsiveness to bacterial lipopolysaccharides Related Publications

• A role for Nod-like receptors in autophagy induced by Shigella infection.
• Calcium, iron and neuronal function.
• Caspase-1 inflammasomes in infection and inflammation.
• Characterization of protein changes associated with sugar beet (Beta vulgaris) resistance and susceptibility to Fusarium oxysporum.
• Cholinergic projections to the suprachiasmatic nucleus and lower subparaventricular zone of diurnal and nocturnal rodents.
• Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.
• Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation.
• Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.
• Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.
• EEG and MEG coherence: measures of functional connectivity at distinct spatial scales of neocortical dynamics.
• Exploring the interaction of ruthenium(II) polypyridyl complexes with DNA using single-molecule techniques.
• Exploring the nickel-catalyzed oxidation of alkenes: a diamination by sulfamide transfer.
• Extraction of polyphenols from white distilled grape pomace: Optimization and modelling.
• Growth stimulation of a proteinase positive Lactococcus lactis strain by a proteinase negative Lactococcus lactis strain.
• Intestinal protozoan and helminth infections in the Municipality San Juan y Martínez, Pinar del Río, Cuba.
• Intracellular NOD-like receptors in host defense and disease.
• Narrow QRS complex tachycardia with unusual atrial activation. What is the mechanism?
• Pacemaker lead infection caused by Aspergillus fumigatus.
• Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.
• Peripheral arterial chemoreceptors and sudden infant death syndrome.
• Premature treatment discontinuation in HIV/HCV-coinfected patients receiving pegylated interferon plus weight-based ribavirin.
• Processing of Rosa rubiginosa: extraction of oil and antioxidant substances.
• RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs.
• Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.
• Samarium lexidronam (153Sm-EDTMP): skeletal radiation for osteoblastic bone metastases and osteosarcoma.
• The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.
• Volatile compounds, odor, and aroma of La Serena cheese high-pressure treated at two different stages of ripening.
• [Not Available.]
• [Not Available.]
• [OWREN'S TEST IN THE CONTROL OF INDIRECT ANTICOAGULANT THERAPEUTICS.]