Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy.

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Research Abstract Details 

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Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Abstract Text:

Junkang Xu,Hui Peng,Jian-Ting Zhang,

Human ABCG2, a member of the ATP-binding cassette transporter superfamily which transports a wide variety of substrates, is highly expressed in placental syncytiotrophoblasts, in the canalicular membranes of liver, in the apical membrane of the small intestine epithelium, and at the luminal surface of the endothelial cells of human brain micro vessels. This strategic tissue localization indicates that ABCG2 plays an important role in absorption, distribution, and elimination of xenobiotics and drugs. High ABCG2 expression has also been detected in many hematological malignancies and solid tumors, indicating that ABCG2 is likely responsible also for the multidrug resistance in cancer chemotherapy. Indeed, ABCG2 can actively transport structurally diverse conjugated- or unconjugated-organic molecules and various anticancer drugs. Many chemo-sensitizing agents have been discovered, which can be developed for increasing drug adsorption and reversing drug resistance in cancer chemotherapy by inhibiting ABCG2 function or expression. This review summarizes current knowledge on ABCG2, its relevance to multidrug resistance and drug disposition, and its ever-growing numbers of substrates and inhibitors.

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Publishing Authors By Initials

J Xu,H Peng,JT Zhang,

For similar neoplasms research abstracts see: neoplasms research

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MEDLINE DATE:

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Current medicinal chemistry

VOLUME: 14

Page Numbers: 689-701

Journal Abbreviation: Curr. Med. Chem.

ISSN: 0929-8673

DAY: 3

MONTH: 12

YEAR: 2007

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Information

Number of References: 135

LANGUAGE: eng

NlmUniqueID: 9440157

Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: genetics

Chemical & Substance for Abstract: Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Information

Substance Name: Neoplasm Proteins

Registry Number: 0

Grant and Affiliation Information for Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy.

AFFILIATION: Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center/Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: CA 94961

ACRONYM: CA

MEDLINETA: Curr Med Chem

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