Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons.

Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons. Research Abstract Details 

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Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons. Abstract Text:

F P Thomas,J E Thomas,S A Sadiq,L H van den Berg,R I Roelofs,N Latov,A P Hays,

An IgM monoclonal autoantibody (M-protein) with anti-Gal(beta 1-3)GalNAc activity from a patient with lower motor neuron disease bound to the surface of motoneurons isolated from bovine spinal cord. The Gal(beta 1-3)GalNAc epitope is shared by the gangliosides GM1 and GD1b and by several glycoproteins in the nervous system, and binding was abolished by preabsorbing the patient's serum with GM1. Antibodies specific for GM1, however, which do not bind to GaL(beta 1-3)GalNAc, did not bind to the motoneurons. This suggests that Gal(beta 1-3)GalNAc bearing glycoproteins or glycolipids other than GM1 are expressed on the surface of motoneurons, while GM1 may be absent or shielded, and that antibody binding to the cell surface might contribute to the development of the motor neuron disease.

Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons. Publishing Authors By Initials

FP Thomas,JE Thomas,SA Sadiq,LH van den Berg,RI Roelofs,N Latov,AP Hays,

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Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neuropathology and experimental neurolo

VOLUME: 49

Page Numbers: 89-95

Journal Abbreviation: J. Neuropathol. Exp. Neurol.

ISSN: 0022-3069

DAY: 5

MONTH: Mar

YEAR: 1990

Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons. Information

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LANGUAGE: eng

NlmUniqueID: 2985192

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Grant and Affiliation Information for Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons.

AFFILIATION: Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, NY 10032.

Country: UNITED STATES

AGENCY: United States NINDS

GRANT: NS117661

ACRONYM: NS

MEDLINETA: J Neuropathol Exp Neurol

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