Human long-chain acyl-CoA synthetase: structure and chromosomal location.

Human long-chain acyl-CoA synthetase: structure and chromosomal location. Research Abstract Details 

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Human long-chain acyl-CoA synthetase: structure and chromosomal location. Abstract Text:

T Abe,T Fujino,R Fukuyama,S Minoshima,N Shimizu,H Toh,H Suzuki,T Yamamoto,

A complementary DNA clone encoding the entire human long-chain acyl-CoA synthetase was isolated and the total 698-amino acid sequence was deduced. The amino acid sequence of human long-chain acyl-CoA synthetase shows 84.9% identity to that of rat long-chain acyl-CoA synthetase. The nucleotide sequences of the protein coding regions between human and rat long-chain acyl-CoA synthetase mRNAs are highly conserved (85.6%), whereas those of the 3' untranslated regions are less conserved (72%). The location of the human long-chain acyl-CoA synthetase gene was identified on chromosome 4 by spot hybridization of flow-sorted chromosomes. Computer-assisted homology search revealed a significant similarity of the enzyme with the enzymes of the luciferase family. Based on this similarity, the structure of human long-chain acyl-CoA synthetase can be divided into five domains: the N-terminus, two domains similar to those in enzymes of the luciferase family, a long gap region between the similar domains and the C-terminus.

Human long-chain acyl-CoA synthetase: structure and chromosomal location. Publishing Authors By Initials

T Abe,T Fujino,R Fukuyama,S Minoshima,N Shimizu,H Toh,H Suzuki,T Yamamoto,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, nucleic acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, nucleic acid research

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Human long-chain acyl-CoA synthetase: structure and chromosomal location. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 111

Page Numbers: 123-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1992

Human long-chain acyl-CoA synthetase: structure and chromosomal location. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Human long-chain acyl-CoA synthetase: structure and chromosomal location. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Nucleic Acid

MESH TERMS: genetics

Chemical & Substance for Abstract: Human long-chain acyl-CoA synthetase: structure and chromosomal location. Information

Substance Name: long-chain-fatty-acid-CoA ligase

Registry Number: EC 6.2.1.3

Grant and Affiliation Information for Human long-chain acyl-CoA synthetase: structure and chromosomal location.

AFFILIATION: Tohoku University Gene Research Center, Miyagi.

Country: JAPAN

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MEDLINETA: J Biochem

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ACCESSION NUMBER: S77596

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