Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Abstract Text:

Qian-Lin Hao,Aswathi A George,Judy Zhu,Lora Barsky,Ewa Zielinska,Xiuli Wang,Mary Price,Shundi Ge,Gay M Crooks,Qian-Lin Hao,Aswathi A George,Judy Zhu,Lora Barsky,Ewa Zielinska,Xiuli Wang,Mary Price,Shundi Ge,Gay M Crooks,

The identity and lineage potential of the cells that initiate thymopoiesis remain controversial. The goal of these studies was to determine, at a clonal level, the immunophenotype and differentiation pathways of the earliest progenitors in human thymus. Although the majority of human CD34(+)lin(-) thymocytes express high levels of CD7, closer analysis reveals that a continuum of CD7 expression exists, and 1% to 2% of progenitors are CD7(-). CD34(+)lin(-) thymocytes were fractionated by CD7 expression and tested for lineage potential in B-lymphoid, T-lymphoid, and myeloid-erythroid conditions. Progressive restriction in lineage potential correlated with CD7 expression, that is, the CD7(hi) fraction produced T and NK cells but lacked B and myelo-erythroid potential, the CD7(int) (CD10(+)) fraction produced B, T, and NK cells, but lacked myelo-erythroid potential. The CD7(-) fraction produced all lymphoid and myelo-erythroid lineages and expressed HSC-associated genes. However, CD34(+)lin(-)CD7(-) thymocytes also expressed early T lymphoid genes Tdt, pTalpha, and IL-7Ralpha and lacked engraftment capacity, suggesting the signals that direct lymphoid commitment and corresponding loss of HSC function are rapidly initiated on arrival of HSC in the human thymus. Thus, differential levels of CD7 identify the progressive stages of lineage commitment in human thymus, initiated from a primitive CD7(-) lympho-myeloid thymic progenitor.

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Publishing Authors By Initials

QL Hao,AA George,J Zhu,L Barsky,E Zielinska,X Wang,M Price,S Ge,GM Crooks,QL Hao,AA George,J Zhu,L Barsky,E Zielinska,X Wang,M Price,S Ge,GM Crooks,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood

VOLUME: 111

Page Numbers: 1318-26

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 24

MONTH: 10

YEAR: 2007

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.

AFFILIATION:

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Blood

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors Related Publications

• (4-Methoxy-3-nitrobenzylideneamino)guanidinium chloride.
• (E)-3-(benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile.
• (Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one.
• (Z)-2-[(1-Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one semicarbazone.
• A CD133-expressing murine liver oval cell population with bilineage potential.
• A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent.
• An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma.
• Bone marrow fails to differentiate into liver epithelium during murine development and regeneration.
• COMPARATIVE STUDIES OF DIPHTHERIA CULTURES OF LOEFFLER'S MEDIUM WITH THE ORIGINAL SWABS TRANSPORTED BY MAIL.
• Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).
• Effect of Pd nanoparticle size on the catalytic hydrogenation of allyl alcohol.
• Effect of particle size on the kinetics of the electrocatalytic oxygen reduction reaction catalyzed by Pt dendrimer-encapsulated nanoparticles.
• Effective monitoring for ractopamine residues in samples of animal origin by SPR biosensor and mass spectrometry.
• Efficient mixing and reactions within microfluidic channels using microbead-supported catalysts.
• Electrokinetic trapping and concentration enrichment of DNA in a microfluidic channel.
• Experimental studies of evolution in guppies: a model for understanding the evolutionary consequences of predator removal in natural communities.
• Extraction of monodisperse palladium nanoparticles from dendrimer templates.
• Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.
• Measuring thermodynamic length.
• Microelectrochemical logic circuits.
• Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.
• Parallel fabrication of RNA microarrays by mechanical transfer from a DNA master.
• Replication of DNA microarrays prepared by in situ oligonucleotide polymerization and mechanical transfer.
• Replication of a DNA microarray.
• Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.
• The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery.
• Titania-supported PdAu bimetallic catalysts prepared from dendrimer-encapsulated nanoparticle precursors.
• Vesicular monoamine transporter 2: role as a novel target for drug development.
• rac-(Z)-2-(2-Thienylmethylene)-1-azabicyclo[2.2.2]octan-3-ol.
• tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.