Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity.

Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity. Research Abstract Details 

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Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity. Abstract Text:

BACKGROUND: Infants are usually protected from various viral infections, including human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7) infections, during the early infantile period by antibodies transferred from their mothers. However, rare cases of exanthem subitum (ES) in neonates have been described in published reports. METHODS: From the infantile patients of febrile illness, HHV-6 and HHV-7 DNA were examined by the polymerase chain reaction method. Antibodies to HHV-6 and HHV-7 were detected by indirect immuno-fluorescence assay and neutralization test. Viral isolation was attempted from the patient's peripheral blood mononuclear cells (PBMC) during the acute phase of febrile illness. RESULTS: Human herpesvirus-6 was verified virologically in two neonates who were clinically diagnosed as ES within the first month of life. Although high copies of HHV-6 DNA were detected in their PBMC during the acute phase, the isolation of HHV-6 from their PBMC was not successful. Neutralizing antibodies to HHV-6 were detected in sera of the acute phase, and those antibodies were considered to be transferred from their mothers. Antibody titers showed fourfold elevation in sera of the convalescent phase. The HHV-6 infection occurred despite the presence of pre-existing maternal antibody. Human herpesvirus-7 and HHV-7 DNA were not detected from their clinical samples. CONCLUSIONS: This observation suggests that HHV-6 infection could not be protected by only humoral immunity.

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Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatrics international : official journal of the

VOLUME: 44

Page Numbers: 281-5

Journal Abbreviation: Pediatr Int

ISSN: 1328-8067

DAY: 21

MONTH: Jun

YEAR: 2002

Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity. Information

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LANGUAGE: eng

NlmUniqueID: 100886002

Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity. Keywords Mesh Terms:

KEYWORDS: Infant, Newborn

MESH TERMS: immunology

Chemical & Substance for Abstract: Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity. Information

Substance Name: Antibodies, Viral

Registry Number: 0

Grant and Affiliation Information for Human herpesvirus-6 infection in neonates: Not protected by only humoral immunity.

AFFILIATION: Division of Pediatrics,Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan.

Country: Australia

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MEDLINETA: Pediatr Int

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