Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain.

Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. Research Abstract Details 

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Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. Abstract Text:

Daniel J Guillaume,M Austin Johnson,Xue-Jun Li,Su-Chun Zhang,

Whether and how in-vitro-produced human neural precursors mature and integrate into the brain are crucial to the utility of human embryonic stem (hES) cells in treating neurological disorders. After transplantation into the ventricles of neonatal immune-deficient mice, hES-cell-derived neural precursors stopped expressing the cell division marker Ki67, except in neurogenic areas, and differentiated into neurons and then glia in a temporal course intrinsic to that of human cells regardless of location. The human cells located in the gray matter became neurons in the olfactory bulb and striatum, whereas those in the white matter produced exclusively glia. Importantly, the grafted human cells formed synapses. Thus, the in-vitro-produced human neural precursors follow their intrinsic temporal program to produce neurons and glia and, in response to environmental signals, generate cells appropriate to their target regions and integrate into the brain.

Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. Publishing Authors By Initials

DJ Guillaume,MA Johnson,XJ Li,SC Zhang,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neuroscience research

VOLUME: 84

Page Numbers: 1165-76

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 1

MONTH: Nov

YEAR: 2006

Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600111

Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. Information

Substance Name: Ki-67 Antigen

Registry Number: 0

Grant and Affiliation Information for Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain.

AFFILIATION: Departments of Anatomy and Neurology, School of Medicine, The Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS046587

ACRONYM: NS

MEDLINETA: J Neurosci Res

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