Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions.

Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions. Research Abstract Details 

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Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions. Abstract Text:

Jihwan Song,Soon-Tae Lee,Wonsuk Kang,Jung-Eun Park,Kon Chu,Song-ee Lee,Taesun Hwang,Hyungmin Chung,Manho Kim,

To test the efficacy of human embryonic stem cell (hESC)-derived neural precursors in an experimental model of Huntington's disease (HD), we differentiated hESC into nestin-positive neural precursors by co-culturing with PA6 stromal cells, and subsequently transplanted them into the striatum of quinolinic acid (QA)-induced HD model. The transplanted animals exhibited a behavioral recovery in the apomorphine-induced rotation test for 3 weeks after transplantation. The transplanted hESC-derived neural precursors were found in both cortex and striatum. They also exhibited some evidence of neuronal differentiation. At the time of examination, no tumor was detected. These results strongly suggest that hESC-derived neural precursors can lead to a behavioral recovery, as well as neuronal differentiation, in the pre-clinical model of HD.

Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions. Publishing Authors By Initials

J Song,ST Lee,W Kang,JE Park,K Chu,SE Lee,T Hwang,H Chung,M Kim,

For similar cells: connective tissue cells: stromal cells research abstracts see: cells: connective tissue cells: stromal cells research

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Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroscience letters

VOLUME: 423

Page Numbers: 58-61

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 14

MONTH: 07

YEAR: 2007

Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions. Information

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LANGUAGE: eng

NlmUniqueID: 7600130

Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions. Keywords Mesh Terms:

KEYWORDS: Stromal Cells

MESH TERMS: transplantation

Chemical & Substance for Abstract: Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions. Information

Substance Name: Quinolinic Acid

Registry Number: 89-00-9

Grant and Affiliation Information for Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions.

AFFILIATION: CHA Stem Cell Institute, Pochon CHA University College of Medicine, and Department of Neurology, Clinical Research Institute, Seoul National University Hospital, South Korea.

Country: Ireland

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MEDLINETA: Neurosci Lett

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