Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats.

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Abstract Text:

Dali Yang,Zhi-Jian Zhang,Michael Oldenburg,Melvin Ayala,Su-Chun Zhang,Dali Yang,Zhi-Jian Zhang,Michael Oldenburg,Melvin Ayala,Su-Chun Zhang,

We show that human embryonic stem cell-derived dopaminergic neurons survived transplantation to the neurotoxin 6-hydroxydopamine-lesioned rat striatum and, in combination with the cells newly differentiated from their progenitors, contributed to locomotive function recovery at 5 months. The animal behavioral improvement was correlated with the dopamine neurons present in the graft. Although the donor cells contained forebrain and midbrain dopamine neurons, the dopamine neurons present in the graft mainly exhibited a midbrain, or nigra, phenotype, suggesting the importance of midbrain dopamine neurons in functional repair. Furthermore, progenies of grafted cells were neurons and glia with greatly diminished mitotic activity by 5 months. Thus, the in vitro-produced human dopamine neurons can functionally engraft in the brain.

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Publishing Authors By Initials

D Yang,ZJ Zhang,M Oldenburg,M Ayala,SC Zhang,D Yang,ZJ Zhang,M Oldenburg,M Ayala,SC Zhang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Stem cells (Dayton, Ohio)

VOLUME: 26

Page Numbers: 55-63

Journal Abbreviation: Stem Cells

ISSN: 1549-4918

DAY: 18

MONTH: 10

YEAR: 2007

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9304532

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats.

AFFILIATION: Department of Anatomy, School of Medicine and Public Health, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

Country: United States

AGENCY: United States NINDS

GRANT: U01-NS046587

ACRONYM: NS

MEDLINETA: Stem Cells

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats Related Publications

• A comparative study on the intercuspal occlusion among TMD patients, malocclusion patients and university students.
• Effect of retinoblastoma gene on human osteosarcoma cell line OS732.
• Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria.
• Intervention by azithromycin on bleomycin-induced lung injury in rats and its mechanisms.
• Method development of adsorbed stationary phase open tubular capillary electrochromatography.
• Supercritical fluid CO2 extraction of colchicine from colchicine Autumnele liliaceae.
• Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot.
• [A case of hypodermiasis with empyema]
• [Analysis of hepatitis G virus genotypes in some areas of China]
• [Autologous dendritic cells eliciting cytotoxicity of bone marrow cells against chronic granulocytic leukemia]
• [Changes of human recombination bone morphogenetic protein-2 in bone and marrow in tail suspended rats]
• [Cloning of the mouse Doc-1R gene by genomic walking]
• [Construction of recombinant adenoviruses carrying human urokinase-type plasminogen activator and its expression in hepatic stellate cells in vitro]
• [Effect of inhibition of telomerase activity on cisplatin-induced apoptosis in K562 cells]
• [Effects of electrical stimulation of lateral hypothalamic area on gastric ischemia-reperfusion injury in rats]
• [Fatal complications in traffic accident injury]
• [Indomethacin induces apoptosis of K562 cells through activation of caspases and elevation of intracellular free calcium]
• [Infection and replication of hepatitis B virus and its clearance mechanism: an overview]
• [Mechanisms underlying dopaminergic neurotoxicity in ischemic cerebral damage]
• [Physiological and pathologic implications for zero-stress state of the esophagus]
• [Protein kinases and Alzheimer's disease]
• [Retroperitoneal laparoscopic unroofing of renal cyst: use of close method]
• [Risk of leukemia among medical X-ray workers in China between 1950 and 1995]
• [Studies on association between lipoprotein lipase gene polymorphisms of Pvu II site and hypertriglyceridemics in Chinese]
• [Study on automatic segmentation of color images applied to blood cells]
• [Study on high performance liquid chromatography/indirect photometric detection of fosfomycin with acridine as detection reagent]
• [Study on the application of number fluorescence density in detecting autoantibodies titer]
• [The effects of surface morphology of calcium phosphate ceramics on apatite formation in dynamic SBF]
• [Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro]
• [Vector propagation algorithm based ECG simulation of bundle branch block]