Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development.

Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development. Research Abstract Details 

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Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development. Abstract Text:

Michelle A Barron,Naomi Blyveis,Samuel C Pan,Cara C Wilson,

Defects in number and function of dendritic cells (DCs) have been observed during HIV-1 infection, so therapeutic HIV-1 vaccine approaches that target or activate DCs may improve vaccine immunogenicity. To determine the potential of recombinant Saccharomyces cerevisiae yeast as an HIV-1 vaccine, we investigated interactions between yeast and human DCs. Yeast induced direct phenotypic maturation of monocyte-derived DCs (MDDCs) and enriched blood myeloid DCs (mDCs), but only indirectly matured blood plasmacytoid DCs (pDCs). Yeast-pulsed MDDCs and blood mDCs produced inflammatory cytokines and stimulated strong allo-reactive T cell proliferation. Both blood DC subsets internalized yeast, and when pulsed with yeast recombinant for HIV-1 Gag protein, both stimulated in vitro expansion of Gag-specific CD8+ memory T cells. These results suggest that S. cerevisiae yeast have potent adjuvant effects on human DCs. Furthermore, recombinant yeast-derived antigens are processed by human blood DCs for MHC class-I cross-presentation. These DC-targeting characteristics of yeast suggest that it may be an effective vaccine vector for induction of HIV-1-specific cellular immune responses.

Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development. Publishing Authors By Initials

MA Barron,N Blyveis,SC Pan,CC Wilson,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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MEDLINE DATE:

Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical immunology

VOLUME: 26

Page Numbers: 251-64

Journal Abbreviation: J. Clin. Immunol.

ISSN: 0271-9142

DAY: 13

MONTH: 05

YEAR: 2006

Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102137

Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development. Information

Substance Name: Gene Products, gag

Registry Number: 0

Grant and Affiliation Information for Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development.

AFFILIATION: Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R21 AI054192

ACRONYM: AI

MEDLINETA: J Clin Immunol

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