Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins.

Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins. Research Abstract Details 

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Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins. Abstract Text:

Hyagriv N Simhan,Jye-Ping Chiao,Donald R Mattison,Steve N Caritis,Hyagriv N Simhan,Jye-Ping Chiao,Donald R Mattison,Steve N Caritis,

OBJECTIVE: The purpose of this study was to determine whether progesterone, 17-alpha-hydroxyprogesterone, and 17-alpha hydroxyprogesterone caproate modulate the Toll-like receptor (TLR) pathway in the response of decidua to lipopolysaccharide. STUDY DESIGN: Cultured human decidual cells were incubated under control conditions, lipopolysaccharide alone, or pretreatment with each of the 3 progestins. Relative expression of 113 genes in the TLR pathway was determined by microarray. RESULTS: We failed to demonstrate a suppression of TLR gene pathway expression in human decidual cells in response to lipopolysaccharide when the cells are pretreated with progestins. Pretreatment with each progestin before lipopolysaccharide resulted in a relative increase in the expression of the proapoptotic molecule, CASP8. There were no differences among the progestins. CONCLUSION: Our data do not support suppression of TLR pathways as a mechanism for the benefit of 17-alpha hydroxyprogesterone caproate. Increased CASP8 gene expression raises the possibility that progestins "prime" the decidual cell to respond with a NFkappaB-mediated inflammatory response.

Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins. Publishing Authors By Initials

HN Simhan,JP Chiao,DR Mattison,SN Caritis,HN Simhan,JP Chiao,DR Mattison,SN Caritis,

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Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of obstetrics and gynecology

VOLUME: 198

Page Numbers: 119.e1-4

Journal Abbreviation: Am. J. Obstet. Gynecol.

ISSN: 1097-6868

DAY: 22

MONTH: 10

YEAR: 2007

Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins. Information

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LANGUAGE: eng

NlmUniqueID: 370476

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Grant and Affiliation Information for Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins.

AFFILIATION: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Country: United States

AGENCY: United States NICHD

GRANT: 5U10 HD047905-02

ACRONYM: HD

MEDLINETA: Am J Obstet Gynecol

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