Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.

Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Research Abstract Details 

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Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Abstract Text:

Khairul I Ansari,Bibhu P Mishra,Subhrangsu S Mandal,

Human encodes several histone H3-Lysine 4 (H3K4) specific methyl-transferases (HMTs) such as MLL1 (mixed lineage leukemia 1), MLL2, MLL3, hSet1 etc, that play critical roles in gene expression. These HMTs are present as distinct multi-protein complexes with several proteins in common. Herein, we have affinity purified and characterized human CpG binding protein (CGBP) and its interacting proteins from human cells. We demonstrated that CGBP is co-purified with three H3K4 specific HMTs MLL1, MLL2, and hSet1. We also performed independent immuno-precipitation of MLL1, MLL2 and hSet1 complexes from human cell and demonstrated that each of these complexes contains CGBP. In addition, CGBP is co-localized with MLL1, MLL2 and hSet1 in vivo and binds to the promoter of MLL target gene HoxA7. Antisense mediated knock down of CGBP diminished the recruitment of MLL1 and down regulated levels of H3K4 trimethylation in HoxA7 promoter affecting its expression. These results demonstrated that CGBP interacts with MLL1, MLL2 as well as hSet1 HMTs and plays critical roles in regulations of MLL target genes.

Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Publishing Authors By Initials

KI Ansari,BP Mishra,SS Mandal,

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Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochimica et biophysica acta

VOLUME: 1779

Page Numbers: 66-73

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 3

MONTH: 12

YEAR: 2007

Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.

AFFILIATION: Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, USA.

Country: Netherlands

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MEDLINETA: Biochim Biophys Acta

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