Human cochlear pathology in aminoglycoside ototoxicity--a review.

Human cochlear pathology in aminoglycoside ototoxicity--a review. Research Abstract Details 

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Human cochlear pathology in aminoglycoside ototoxicity--a review. Abstract Text:

E H Huizing,J C de Groot,

The pathological findings due to aminoglycoside ototoxicity in man, as reported in the literature, is reviewed. 21 cases (40 ears) have been studied after serial sectioning, 8 cases (12 ears) have been investigated by the microdissection and surface preparation technique. The combination of both methods provides maximal information. OHCs are primarily affected, followed by IHC loss. Degeneration starts at the basal coil and proceeds towards the apex. The stria vascularis becomes involved in all turns. It is not clear whether stria degeneration is primary or secondary. Supporting cells, nerve fibres and ganglion cells degenerate secondary to hair cell loss. In some cases ingrowth of myelinated nerve fibres in areas with complete destruction of the organ of Corti has been observed. Ototoxic lesions can be asymmetric. Attention is drawn to the audiometric Z-curve in moderate lesions.

Human cochlear pathology in aminoglycoside ototoxicity--a review. Publishing Authors By Initials

EH Huizing,JC de Groot,

For similar pathological conditions, signs and symptoms: pathologic processes: nerve degeneration research abstracts see: pathological conditions, signs and symptoms: pathologic processes: nerve degeneration research

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Human cochlear pathology in aminoglycoside ototoxicity--a review. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 436

Page Numbers: 117-25

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1987

Human cochlear pathology in aminoglycoside ototoxicity--a review. Information

Number of References: 23

LANGUAGE: eng

NlmUniqueID: 370355

Human cochlear pathology in aminoglycoside ototoxicity--a review. Keywords Mesh Terms:

KEYWORDS: Nerve Degeneration

MESH TERMS: drug effects

Chemical & Substance for Abstract: Human cochlear pathology in aminoglycoside ototoxicity--a review. Information

Substance Name: Aminoglycosides

Registry Number: 0

Grant and Affiliation Information for Human cochlear pathology in aminoglycoside ototoxicity--a review.

AFFILIATION: Department of Otolaryngology, University of Utrecht, The Netherlands.

Country: SWEDEN

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MEDLINETA: Acta Otolaryngol Suppl

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