Human brain glycogen content and metabolism: implications on its role in brain energy metabolism.

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Research Abstract Details 

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Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Abstract Text:

Oz,Elizabeth R Seaquist,Anjali Kumar,Amy B Criego,Luke E Benedict,Jyothi P Rao,Pierre-Gilles Henry,Pierre-Francois Van De Moortele,Rolf Gruetter,

The adult brain relies on glucose for its energy needs and stores it in the form of glycogen, primarily in astrocytes. Animal and culture studies indicate that brain glycogen may support neuronal function when the glucose supply from the blood is inadequate and/or during neuronal activation. However, the concentration of glycogen and rates of its metabolism in the human brain are unknown. We used in vivo localized 13C-NMR spectroscopy to measure glycogen content and turnover in the human brain. Nine healthy volunteers received intravenous infusions of [1-(13)C]glucose for durations ranging from 6 to 50 h, and brain glycogen labeling and washout were measured in the occipital lobe for up to 84 h. The labeling kinetics suggest that turnover is the main mechanism of label incorporation into brain glycogen. Upon fitting a model of glycogen metabolism to the time courses of newly synthesized glycogen, human brain glycogen content was estimated at approximately 3.5 micromol/g, i.e., three- to fourfold higher than free glucose at euglycemia. Turnover of bulk brain glycogen occurred at a rate of 0.16 micromol.g-1.h-1, implying that complete turnover requires 3-5 days. Twenty minutes of visual stimulation (n=5) did not result in detectable glycogen utilization in the visual cortex, as judged from similar [13C]glycogen levels before and after stimulation. We conclude that the brain stores a substantial amount of glycogen relative to free glucose and metabolizes this store very slowly under normal physiology.

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Publishing Authors By Initials

G Oz,ER Seaquist,A Kumar,AB Criego,LE Benedict,JP Rao,PG Henry,PF Van De Moortele,R Gruetter,

For similar investigative techniques: physical stimulation: photic stimulation research abstracts see: investigative techniques: physical stimulation: photic stimulation research

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Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Endocrinology and

VOLUME: 292

Page Numbers: E946-51

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 28

MONTH: 11

YEAR: 2006

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Information

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LANGUAGE: eng

NlmUniqueID: 100901226

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Keywords Mesh Terms:

KEYWORDS: Photic Stimulation

MESH TERMS: physiology

Chemical & Substance for Abstract: Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Information

Substance Name: Glycogen

Registry Number: 9005-79-2

Grant and Affiliation Information for Human brain glycogen content and metabolism: implications on its role in brain energy metabolism.

AFFILIATION: Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th St. SE, Minneapolis, MN 55455, USA. gulin@cmrr.umn.edu

Country: United States

AGENCY: United States NINDS

GRANT: R21-NS-45519

ACRONYM: NS

MEDLINETA: Am J Physiol Endocrinol Metab

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