Human bone allografts can induce T cells with high affinity for donor antigens.

Human bone allografts can induce T cells with high affinity for donor antigens. Research Abstract Details 

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Human bone allografts can induce T cells with high affinity for donor antigens. Abstract Text:

R L Deijkers,G J Bouma,E M van der Meer-Prins,P E Huysmans,A H Taminiau,F H Claas,

We analysed the cellular immune response in ten transplantations of different massive bone allografts, of which five had a poor clinical outcome. Cytotoxic T lymphocytes (CTL) and T helper lymphocytes (TH) against mismatched donor antigens were found in all patients. More importantly, CTL with a high affinity for donor antigens were found in five cases. High-affinity CTL need no CD8 molecule to stabilise the antigen binding and are strongly associated with rejection of heart and corneal transplants. Even after removal of most of the bone-marrow cells, we found high-affinity CTL and high TH frequencies. This T-cell response could be detected over a period of years. We conclude that frozen bone allografts can induce high-affinity donor-specific CTL. The present assay allows qualification and quantification of the levels of CTL and TH in the blood. This approach may be helpful in studying the effect of the immune response on the outcome of the graft.

Human bone allografts can induce T cells with high affinity for donor antigens. Publishing Authors By Initials

RL Deijkers,GJ Bouma,EM van der Meer-Prins,PE Huysmans,AH Taminiau,FH Claas,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

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Human bone allografts can induce T cells with high affinity for donor antigens. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of bone and joint surgery. British vol

VOLUME: 81

Page Numbers: 538-44

Journal Abbreviation:

ISSN: 0301-620X

DAY: 14

MONTH: May

YEAR: 1999

Human bone allografts can induce T cells with high affinity for donor antigens. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375355

Human bone allografts can induce T cells with high affinity for donor antigens. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: immunology

Chemical & Substance for Abstract: Human bone allografts can induce T cells with high affinity for donor antigens. Information

Substance Name: Antigens, CD8

Registry Number: 0

Grant and Affiliation Information for Human bone allografts can induce T cells with high affinity for donor antigens.

AFFILIATION: Department of Immunohaematology, Leiden University Medical Centre, The Netherlands.

Country: ENGLAND

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MEDLINETA: J Bone Joint Surg Br

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