Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.

Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. Research Abstract Details 

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Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. Abstract Text:

Guylaine ,Louis M Mansky,Reuben S Harris,

Over 40 million people worldwide currently have HIV/AIDS. Many antiretroviral drugs have proven effective, but drug-resistant HIV variants frequently emerge to thwart treatment efforts. Reverse transcription errors undoubtedly contribute to drug resistance, but additional significant sources of viral genetic variation are debatable. The human APOBEC3F and APOBEC3G proteins can potently inhibit retrovirus infection by a mechanism that involves retroviral cDNA cytosine deamination. Here we review the current knowledge on the mechanism of APOBEC3-dependent retrovirus restriction and discuss whether this innate host-defense system actively contributes to HIV genetic variation.

Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. Publishing Authors By Initials

G ,LM Mansky,RS Harris,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

PUBMED ID PMID:

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Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. Journal Published:

PUBLICATION TYPE: Review

Journal: AIDS reviews

VOLUME: 8

Page Numbers: 148-57

Journal Abbreviation:

ISSN: 1139-6121

DAY: 3

MONTH: 12

YEAR: 2007

Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101134876

Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: immunology

Chemical & Substance for Abstract: Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. Information

Substance Name: Cytosine Deaminase

Registry Number: EC 3.5.4.1

Grant and Affiliation Information for Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.

AFFILIATION: University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics, Minneapolis, MN 55455, USA.

Country: Spain

AGENCY: United States NIGMS

GRANT: GM56615

ACRONYM: GM

MEDLINETA: AIDS Rev

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